This doctoral thesis explores the mechanisms of hypoxic-ischemic brain injury in preterm
and term-equivalent fetuses, the role of potential biomarkers for compromise and neuronal …

Perinatal asphyxia is thought to be a major cause of subsequent neurological deficits.
Pathological studies suggest that many of these events occur before birth. However, the …

Background and Purpose—Electroencephalographic recovery is predictive of outcome after
perinatal hypoxia–ischemia, but it is unknown whether early changes in …

Perinatal hypoxic-ischemic encephalopathy (HIE) is an important cause of brain injury in the
newborn. It may lead to a variety of different long-term neurological sequelaes; from mild …

There is compelling evidence that 72 h of moderate hypothermia initiated within 2 to 6 h after
hypoxia-ischemia can protect against brain injury, disability and death in term newborn …

Introduction Neonates with mild hypoxic-ischemic encephalopathy (HIE) in the first 6 hours
after birth are not eligible for therapeutic hypothermia, although there is increasing evidence …

Asphyxia can cause neurologic damage in the fetus, hot there are few data relating severity
or duration of asphyxia to the degree of cerebral damage. We report cerebral histologic and …

This thesis explores potential mechanisms of brain injury in preterm and term fetuses. I first
demonstrated that prolonged umbilical cord occlusion (UCO) in un-anaesthetised near-term …

Spontaneous antenatal hypoxia is associated with high risk of adverse outcomes, however,
there is little information on neural adaptation to labor-like insults. Chronically instrumented …

Perinatal hypoxia-ischemia resulting in death or lifelong disabilities remains a major clinical
disorder. Neonatal models of hypoxia-ischemia in rodents have enhanced our …