The benefits of creatine supplementation have been reported in a broad range of central
nervous system diseases, including depression, although the mechanisms underlying these …

Creatine has been shown to play a significant role in the pathophysiology and treatment of
major depressive disorder (MDD) in preclinical and clinical studies. However, the biological …

Stress contributes to numerous psychopathologies, including memory impairment, and
threatens one's well-being. It has been reported that creatine supplementation potentially …

Creatine is an antioxidant, neuromodulator and key regulator of energy metabolism shown
to improve depressive symptoms in humans and animals, especially in females. To better …

Impairments in bioenergetic function, cellular resiliency, and structural plasticity are
associated with the pathogenesis of mood disorders. Preliminary evidence suggests that …

Antidepressants increase adult hippocampal neurogenesis in animal models, but the
underlying molecular mechanisms are unknown. In this study, we used human hippocampal …

The potential role of metabolic impairments in the pathophysiology of depression is
motivating researchers to evaluate the treatment efficacy of creatine, a naturally occurring …

Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid
remission, but elicits some side effects that limit its use. In an attempt to investigate a safer …

[Purpose] Chronic stress can lead to mood-related psychomotor behaviors such as despair.
Decreased hippocampal neurogenesis has been observed in patients with depression and …

BACKGROUND: Volumetric changes and glial pathology have been reported in the central
nervous system (CNS) of patients with depressive disorder, an illness often associated with …