Retinoic acid-mediated anti-inflammatory responses in equine immune cells stimulated by LPS and allogeneic mesenchymal stem cells

L Abdelhamid, H Hussein, M Ghanem… - Research in veterinary …, 2017 - Elsevier
Retinoic acid (RA), an active metabolite of vitamin A, has shown potential therapeutic
immunomodulatory properties. Allogeneic mesenchymal stem cells (MSCs)-based therapy …

Priming equine bone marrow-derived mesenchymal stem cells with proinflammatory cytokines: implications in immunomodulation–immunogenicity balance, cell …

L Barrachina, AR Remacha, A Romero… - Stem Cells and …, 2017 - liebertpub.com
Mesenchymal stem cells (MSCs) have a great potential for treating equine musculoskeletal
injuries. Although their mechanisms of action are not completely known, their …

The immunomodulatory function of equine MSCs is enhanced by priming through an inflammatory microenvironment or TLR3 ligand

JM Cassano, LV Schnabel, MB Goodale… - Veterinary immunology …, 2018 - Elsevier
Mesenchymal stem cells (MSCs) have the therapeutic potential to treat a variety of
inflammatory and degenerative disease processes, however the effects of the tissue …

[HTML][HTML] The immunomodulation–immunogenicity balance of equine Mesenchymal Stem Cells (MSCs) is differentially affected by the immune cell response …

A Cequier, FJ Vázquez, A Romero, A Vitoria… - Frontiers in Veterinary …, 2022 - frontiersin.org
The immunomodulatory properties of equine mesenchymal stem cells (MSCs) are important
for their therapeutic potential and for their facilitating role in their escape from immune …

[HTML][HTML] Pre-conditioning of equine bone marrow-derived mesenchymal stromal cells increases their immunomodulatory capacity

V Caffi, G Espinosa, G Gajardo, N Morales… - Frontiers in veterinary …, 2020 - frontiersin.org
Mesenchymal stem/stromal cells (MSCs) are increasingly explored for the treatment of
degenerative and inflammatory diseases in human and veterinary medicine. One of the key …

[HTML][HTML] The potential of mesenchymal stem cells to treat systemic inflammation in horses

ES MacDonald, JG Barrett - Frontiers in Veterinary Science, 2020 - frontiersin.org
One hallmark of mesenchymal stem cells (MSCs) is the ability to differentiate into multiple
tissue types which assists in tissue regeneration. Another hallmark of MSCs is their potent …

[HTML][HTML] Equine mesenchymal stromal cells and embryo-derived stem cells are immune privileged in vitro

YZ Paterson, N Rash, ER Garvican, R Paillot… - Stem cell research & …, 2014 - Springer
Introduction Autologous mesenchymal stem cells (MSCs) are an attractive concept in
regenerative medicine, but their mechanism of action remains poorly defined. No immune …

The systemic cellular immune response against allogeneic mesenchymal stem cells is influenced by inflammation, differentiation and MHC compatibility: in vivo study …

A Cequier, FJ Vázquez, A Vitoria, E Bernad… - Frontiers in Veterinary …, 2024 - frontiersin.org
The effectiveness and safety of allogeneic mesenchymal stem/stromal cells (MSCs) can be
affected by patient's immune recognition. Thus, MSC immunogenicity and their …

Comparative analysis of the immunomodulatory properties of equine adult-derived mesenchymal stem cells

DD Carrade, MW Lame, MS Kent, KC Clark… - Cell …, 2012 - journals.sagepub.com
Mesenchymal stem cells (MSCs) derived from bone marrow (BM), adipose tissue (AT),
umbilical cord blood (CB), and umbilical cord tissue (CT) are increasingly being used to treat …

Effect of inflammatory environment on equine bone marrow derived mesenchymal stem cells immunogenicity and immunomodulatory properties

L Barrachina, AR Remacha, A Romero… - Veterinary immunology …, 2016 - Elsevier
Mesenchymal stem cells (MSCs) are being investigated for the treatment of equine joint
diseases because of their regenerative potential. Recently, the focus mainly has addressed …