It has been reported that restriction of reperfusion after thrombolytic therapy in ischemic
stroke may reduce tissue plasminogen activator (tPA) adverse effects and extend its time …

Late treatment with tissue plasminogen activator (tPA) leads to reperfusion injury and poor
outcome in ischemic stroke. We have recently shown the beneficial effects of local brain …

Thrombolysis (T) is limited by reperfusion-associated injury and the short therapeutic
window after stroke onset. The present study investigates whether hypothermia alone or in …

Therapeutic hypothermia has shown neuroprotective promise, but whether it can be used to
improve outcome in stroke has yet to be determined in patients. Recombinant tissue …

Background Hypothermia is neuroprotective in experimental stroke and may extend the so
far limited therapeutic time window for thrombolysis. Therefore, hypothermia of 34° C and its …

Background and Purpose—Previously, we have shown that hyperthermia significantly
increased neuronal damage after ischemic injury in a focal embolic model of stroke in rats …

The potential for hypothermia as a neuroprotectant during stroke has led to its increase in
clinical use. At the same time, combination pharmaceutical therapies for ischemic stroke …

Reperfusion therapies for stroke diminish in effectiveness and safety as time to treatment
increases. Hypothermia neuroprotection for stroke is established, but its clinical translation …

Background Based on empirical experience, hypothermia has long been known to be a
potent putative neuroprotectant. Recent insights into the mechanisms of cerebral ischemia …

Background Thrombolysis and endovascular thrombectomy are the primary treatment for
ischemic stroke. However, due to the limited time window and the occurrence of adverse …