Background: The renin-angiotensin system (RAS) is activated in heart failure (HF) and
inhibition of RAS is a mainstay therapy for HF. Angiotensin-converting enzyme 2 (ACE2) and …

Abstract Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase that
metabolizes several peptides, including the degradation of angiotensin (Ang) II, a peptide …

Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …

Background ACE2 is a novel homologue of angiotensin converting enzyme (ACE). ACE2 is
highly expressed in human heart and animal data suggest that ACE2 is an essential …

Abstract Angiotensin II (Ang II), a bioactive peptide of the renin–angiotensin system (RAAS),
plays an important role in the development of cardiovascular diseases (CVD) …

Objectives: We sought to determine whether circulating soluble angiotensin-converting
enzyme 2 (sACE2) is increased in the plasma of patients with heart failure (HF) …

Angiotensin-converting enzyme 2 (ACE2) converts the vasopressor angiotensin II (Ang II)
into angiotensin (1-7)[Ang (1-7)], a peptide reported to have vasodilatory and …

BACKGROUND: Angiotensin-converting enzyme 2 (ACE2) is an endogenous
counterregulator of the renin-angiotensin system. The relationship between soluble ACE2 …

Background—Angiotensin-converting enzyme 2 (ACE2) has emerged as a novel regulator
of cardiac function and arterial pressure by converting angiotensin II (Ang II) into the …

Background—The formation of angiotensin-(1-7) from either angiotensin (Ang) I or Ang II in
failing human hearts is not well understood. Methods and Results—Angiotensinase activity …