Abstract Globally, there are 500,000 annual new cases of hormone-sensitive breast cancer
in premenopausal women; 400,000 of these occur in women in low and middle income …

Surgical oophorectomy should have a major place in treatment of pre-menopausal women
with hormone-receptor positive breast cancer. New data on increasing efficacy and multiple …

One third of annual new cases of breast cancer globally are now hormone receptor–positive
tumors in premenopausal women from low-and middle-income countries. For this subgroup …

While the preponderance of current scientific presentations on breast cancer therapies has
focused on chemotherapeutic strategies, targeted therapy with tyrosine kinase inhibitors and …

• Individual patient (in researchers' experiences) versus global public health treatment
paradigms, with limited consideration of the equity issues 14 associated with these …

Adjuvant surgical oophorectomy is an effective and remarkably cost effective treatment for
premenopausal women with hormone receptor positive operable breast cancer. Previously …

PURPOSE: In 1992, the Early Breast Cancer Trialists' Collaborative Group reported that a
meta-analysis of six randomized trials in European and North American women begun from …

Purpose Worldwide, approximately 750,000 new cases of breast cancer are diagnosed
annually in premenopausal women with limited economic resources. Longer-term survival …

The role of oophorectomy in the treatment of breast cancer is known for over 100 years.
Ovarian ablation has a relatively large positive effect on both disease-free survival (DFS) …

Opinion statement Oophorectomy was found to cause regression of advanced breast cancer
toward the end of the 19th century. Decades later, the discovery that estrogen plays a central …