Translational Advances in the Field of Pulmonary Hypertension.From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth …

SS Pullamsetti, R Savai, W Seeger… - American journal of …, 2017 - atsjournals.org
Pulmonary arterial hypertension (PAH) has been frequently compared with a type of
malignant disease and has an incredible number of pathogenic mechanisms similar to …

The cancer theory of pulmonary arterial hypertension

O Boucherat, G Vitry, I Trinh, R Paulin… - Pulmonary …, 2017 - journals.sagepub.com
Pulmonary arterial hypertension (PAH) remains a mysterious killer that, like cancer, is
characterized by tremendous complexity. PAH development occurs under sustained and …

Basic science of pulmonary arterial hypertension for clinicians: new concepts and experimental therapies

SL Archer, EK Weir, MR Wilkins - Circulation, 2010 - Am Heart Assoc
Pulmonary arterial hypertension (PAH) is a syndrome in which pulmonary arterial
obstruction increases pulmonary vascular resistance, which leads to right ventricular (RV) …

Pulmonary arterial hypertension: New pathophysiological insights and emerging therapeutic targets

A Bourgeois, J Omura, K Habbout, S Bonnet… - The international journal …, 2018 - Elsevier
Pulmonary arterial hypertension (PAH) encompasses a group of clinical entities
characterized by sustained vasoconstriction and progressive vascular remodeling that act in …

Pathogenesis of pulmonary arterial hypertension: lessons from cancer

C Guignabert, L Tu, M Le Hiress… - European …, 2013 - Eur Respiratory Soc
Although the causal pathomechanisms contributing to remodelling of the pulmonary
vascular bed in pulmonary arterial hypertension (PAH) are still unclear, several analogous …

From oncoproteins/tumor suppressors to microRNAs, the newest therapeutic targets for pulmonary arterial hypertension

R Paulin, A Courboulin, M Barrier, S Bonnet - Journal of molecular …, 2011 - Springer
Pulmonary arterial hypertension (PAH) is a disease of the pulmonary vasculature
characterized by constricted and remodeled pulmonary arteries. This phenomenon is …

Translational Advances in the Field of Pulmonary Hypertension.Focusing on Developmental Origins and Disease Inception for the Prevention of Pulmonary …

BA Maron, SH Abman - American journal of respiratory and critical …, 2017 - atsjournals.org
Persistent challenges in managing pulmonary vascular disease progression and poor
outcomes, despite the aggressive use of current drug therapies, highlight the need for …

Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right …

E Spiekerkoetter, EA Goncharova… - Pulmonary …, 2019 - journals.sagepub.com
In order to intervene appropriately and develop disease-modifying therapeutics for
pulmonary arterial hypertension, it is crucial to understand the mechanisms of disease …

Translational Advances in the Field of Pulmonary Hypertension.Translating MicroRNA Biology in Pulmonary Hypertension. It Will Take More Than “miR” …

HJ Chun, S Bonnet, SY Chan - American journal of respiratory and …, 2017 - atsjournals.org
Pulmonary hypertension (PH) is a complex pulmonary vascular condition with increasing
global prevalence and with particularly severe forms, such as pulmonary arterial …

Vascular remodeling in pulmonary arterial hypertension: multiple cancer-like pathways and possible treatment modalities

S Sakao, K Tatsumi - International journal of cardiology, 2011 - Elsevier
Most patients with severe pulmonary arterial hypertension (PAH) at the time of diagnosis
tend to demonstrate persistent structural alterations in their microscopically small pulmonary …