Although multiple sclerosis (MS) is considered to be a CD4, Th17-mediated autoimmune
disease, supportive evidence is perhaps circumstantial, often based on animal studies, and …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Once thought to be primarily driven by T cells, B cells are emerging as central …

Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic,
particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic …

B cell depletion via anti-CD20 antibodies is a highly effective treatment for multiple sclerosis
(MS). However, little is known about the maturation/activation stage of the returning B cell …

The pathogenic role for B cells in the context of relapsing remitting multiple sclerosis (MS) is
incompletely defined. Although classically considered a T cell-mediated disease, B cell …

Recent evidence suggests that B‐and T‐cell interactions may be paramount in relapsing‐
remitting MS (RRMS) disease pathogenesis. We hypothesized that memory B‐cell pools …

The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple
sclerosis (MS) and primary progressive MS has led to a conceptual shift in the …

Autoimmune B cells play a major role in mediating tissue damage in multiple sclerosis (MS).
In MS, B cells are believed to cross the blood-brain barrier and undergo stimulation, antigen …

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
with no clear etiology. Until recently, most studies have emphasized the role of T cells in the …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) where immunopathology is thought to be mediated by myelin-reactive CD4+ T …