Neutrophils contribute to demyelinating autoimmune diseases, yet their phenotype and
functions have been elusive to date. Here, we demonstrate that ICAM1 surface expression …

During experimental autoimmune encephalomyelitis (EAE), autoreactive Th1 T cells invade
the CNS. Before performing their effector functions in the target organ, T cells must …

Multiple sclerosis is considered to be initiated by a deregulated, myelin-specific T cell
response. However, the formation of inflammatory CNS lesions and the contribution of …

Experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple
sclerosis (MS), is mediated by myelinspecific autoreactive T cells that cause inflammation …

Molecular interventions that limit pathogenic CNS inflammation are used to treat
autoimmune conditions such as multiple sclerosis (MS). Remarkably, IL-1β–knockout mice …

In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis
(MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 …

Experimental autoimmune encephalomyelitis (EAE) has been used as an animal model of
multiple sclerosis to identify pathogenic cytokines that could be therapeutic targets …

Experimental autoimmune encephalomyelitis (EAE) is a well-characterized animal model of
multiple sclerosis. During the early phase of EAE, infiltrating monocytes and monocyte …

Neuroinflammatory roles of central innate immunity in brain parenchyma are well-regarded
in the progression of neurodegenerative disorders including Alzheimer's disease (AD) …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS) leading to CNS inflammation and neurodegeneration. Current anti-inflammatory …