Repurposing non-cancer Drugs in Oncology–How many drugs are out there?

P Pantziarka, V Sukhatme, L Meheus, V Sukhatme… - bioRxiv, 2017 - biorxiv.org
Background Drug repurposing can speed up access to new therapeutic options for cancer
patients. With more than 2000 drugs approved worldwide and 6 relevant targets per drug on …

Drug repurposing in oncology—patient and health systems opportunities

F Bertolini, VP Sukhatme, G Bouche - Nature reviews Clinical oncology, 2015 - nature.com
In most countries, healthcare service budgets are not likely to support the current explosion
in the cost of new oncology drugs. Repurposing the large arsenal of approved, non …

Drug repurposing for cancer therapy, easier said than done

A Gonzalez-Fierro, A Dueñas-González - Seminars in cancer biology, 2021 - Elsevier
Drug repurposing for cancer therapy is currently a hot topic of research. Theoretically, in
contrast to the known hurdles of developing new molecular entities, the approach of …

Drug repurposing—an emerging strategy in cancer therapeutics

KS Turabi, A Deshmukh, S Paul, D Swami… - Naunyn-Schmiedeberg's …, 2022 - Springer
Cancer is a complex disease affecting millions of people around the world. Despite
advances in surgical and radiation therapy, chemotherapy continues to be an important …

Repurposing drugs in oncology: next steps

C Verbaanderd, L Meheus, I Huys, P Pantziarka - Trends in cancer, 2017 - cell.com
The repurposing of existing non-cancer drugs is a potential source of new treatment options
for cancer patients with high unmet medical needs. While scientific research is progressing …

Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Drug repurposing in oncology: a systematic review of randomized controlled clinical trials

I Ioakeim-Skoufa, N Tobajas-Ramos, E Menditto… - Cancers, 2023 - mdpi.com
Simple Summary Exploring the possibility of using well-known marketed drugs in new
therapeutic indications, commonly known as drug repurposing, offers certain advantages …

Can any drug be repurposed for cancer treatment? A systematic assessment of the scientific literature

N Stransky, P Ruth, M Schwab, MW Löffler - Cancers, 2021 - mdpi.com
Simple Summary Drug repurposing strategies utilize drugs, already approved by regulatory
authorities, to test their efficacy against different diseases. While this approach is …

Drug repurposing in cancer: now and beyond

AH Eid - Current Medicinal Chemistry, 2021 - ingentaconnect.com
Drug repurposing, also called drug repositioning, is an attractive approach that seeks to
identify new targets or treatments for existing drugs. This approach saves not only significant …

“Hard” drug repurposing for precision oncology: the missing link?

P Pantziarka, G Bouche, N André - Frontiers in Pharmacology, 2018 - frontiersin.org
Drug repurposing is at the heart of precision oncology. The move from tissue-or cancer-
specific treatments to genomic-or actionable-target treatments necessarily entails the reuse …