Background The motor thalamus is a key nodal point in the pallidothalamocortical “motor”
circuit, which has been implicated in the pathogenesis of Parkinson's disease (PD) and …

Deep brain stimulation (DBS) of the internal segment of the globus pallidus (GPi) and the
subthalamic nucleus (STN) are effective for the treatment of advanced Parkinson's disease …

Although there is general consensus that deep brain stimulation (DBS) yields substantial
clinical benefit in patients with Parkinson's disease (PD), the therapeutic mechanism of DBS …

Deep brain stimulation (DBS) involves the delivery of continuous, fixed-frequency electrical
pulses to specific brain regions; however the reliance of therapeutic benefit on the fixed …

The pedunculopontine tegmental nucleus (PPN) is being explored as a site for deep brain
stimulation (DBS) for the treatment of patients with medically refractory gait and postural …

Competing theories seek to account for the therapeutic effects of high-frequency deep brain
stimulation (DBS) of the internal globus pallidus (GPi) for medically intractable Parkinson's …

Theoretical and experimental analyses of deep brain stimulation (DBS) in the subthalamic
nucleus (STN) show both excitatory and inhibitory effects on the neural elements …

Deep-brain stimulation (DBS) of the globus pallidus pars interna (GPi) is a highly effective
therapy for movement disorders, yet its mechanism of action remains controversial. Inhibition …

Deep brain stimulation (DBS), a surgical therapy for advanced Parkinson's disease (PD), is
known to change neuronal activity patterns in the pallidothalamic circuit. Whether these …

Recent physiological and anatomical studies have yielded considerable insight into the role
of the basal ganglia in the pathophysiology of Parkinson's disease. Experiments in monkeys …