Abstract Purpose of Review Preeclampsia affects 3–4% of pregnancies with few treatment
options to reduce maternal and fetal harm. Recent evidence that targeting the complement …

The complement system protects the host against invading organisms, initiates inflammation
and dispose of immune complexes and the products of inflammatory injury. The complement …

Preeclampsia is one of the leading causes of maternal and neonatal mortality and morbidity
worldwide, affecting 2–8% of all pregnancies. Studies suggest a link between complement …

The complement system is critical to human health owing to its central role in host defense
and innate immunity. During pregnancy, the complement system must be appropriately …

Increasing evidence suggests that preeclampsia is associated with complement
dysregulation. The origin of complement dysregulation in preeclampsia is unknown, and …

Early-onset pre-eclampsia is characterized by decreased placental perfusion, new-onset
hypertension, angiogenic imbalance, and endothelial dysfunction associated with excessive …

Abstract Purpose of Review Significant and intricate immune adaptations are essential for
the establishment and maintenance of normal pregnancy. Preeclampsia is a morbid …

Preeclampsia is a major cause of maternal and neonatal morbidity and mortality. In mouse
models, complement activation in the placenta is associated with abnormal placental …

Preeclampsia (PE) is a life-threatening, pregnancy-induced disease and a leading cause of
maternal and fetal morbidity and mortality. Despite considerable research, the causes of PE …

The complement cascade is activated in normal pregnancy, and excessive complement
activation propagates the systemic inflammatory response in severe preeclampsia …