Glutamatergic system and mTOR signaling pathway have been proposed to be important
targets for pharmacological treatment of major depressive disorder. Previous studies have …

Inosine is a purine nucleoside formed by the breakdown of adenosine that elicits an
antidepressant-like effect in mice through activation of adenosine A 1 and A 2A receptors …

Inosine is an endogenous purine nucleoside, which is formed during the breakdown of
adenosine. The adenosinergic system was already described as capable of modulating …

Guanosine is an extracellular signaling molecule implicated in the modulation of
glutamatergic transmission and neuroprotection. The present study evaluated the …

The modulation of N-methyl-D-aspartate receptor (NMDAR) and l-arginine/nitric oxide (NO)
pathway is a therapeutic strategy for treating depression and neurologic disorders that …

Glutamatergic processes are strongly implicated in the pathophysiology and treatment of
depression, including the antidepressant effects of N-methyl-d-aspartate (NMDA) receptor …

N-methyl-D-aspartate receptor (NMDAR) modulators induce rapid and sustained
antidepressant like-activity in rodents through a molecular mechanism of action that involves …

Inosine, a major breakdown product of adenosine by the enzyme adenosine deaminase,
binds to adenosine receptors and initiates intracellular signaling events. Adenosine and …

Background Spermine is one of the naturally occurring ligands that influence the function of
the N-methyl-d-aspartate receptor. Similar to other endogenous polyamines present in …

This study investigated the effect of melatonin in the mouse tail suspension test (TST), and
the contribution of N-methyl-d-aspartate (NMDA) receptors and the l-arginine-nitric oxide …