Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease

AC Boese, SC Kim, KJ Yin, JP Lee… - American Journal of …, 2017 - journals.physiology.org
Sex differences between women and men are often overlooked and underappreciated when
studying the cardiovascular system. It has been long assumed that men and women are …

Gender, sex hormones, and vascular tone

JM Orshal, RA Khalil - American Journal of Physiology …, 2004 - journals.physiology.org
The greater incidence of hypertension and coronary artery disease in men and
postmenopausal women compared with premenopausal women has been related, in part, to …

Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan

AE Stanhewicz, MM Wenner… - American Journal of …, 2018 - journals.physiology.org
Diseases of the cardiovascular system are the leading cause of morbidity and mortality in
men and women in developed countries, and cardiovascular disease (CVD) is becoming …

Gender-based research underscores sex differences in biological processes, clinical disorders and pharmacological interventions

SR Bernstein, C Kelleher, RA Khalil - Biochemical Pharmacology, 2023 - Elsevier
Earlier research has presumed that the male and female biology is similar in most organs
except the reproductive system, leading to major misconceptions in research interpretations …

Molecular and cellular basis of cardiovascular gender differences

ME Mendelsohn, RH Karas - Science, 2005 - science.org
Cardiovascular diseases (CVDs), the major cause of morbidity and mortality for both men
and women, occur uncommonly in premenopausal women, but their incidence rises sharply …

Sex and the cardiovascular system: the intriguing tale of how women and men regulate cardiovascular function differently

VH Huxley - Advances in physiology education, 2007 - journals.physiology.org
The ability to recognize and appreciate from a reproductive standpoint that males and
females possess different attributes has been long standing. Only more recently have we …

Sex hormones in the cardiovascular system

RL dos Santos, FB da Silva, RF Ribeiro Jr… - … molecular biology and …, 2014 - degruyter.com
Gender-associated differences in the development of cardiovascular diseases have been
described in humans and animals. These differences could explain the low incidence of …

The different role of sex hormones on female cardiovascular physiology and function: not only oestrogens

S Salerni, S Di Francescomarino… - European journal of …, 2015 - Wiley Online Library
Human response to different physiologic stimuli and cardiovascular (CV) adaptation to
various pathologies seem to be gender specific. Sex‐steroid hormones have been …

Sex steroids and vascular responses in hypertension and aging

X Qiao, KR McConnell, RA Khalil - Gender medicine, 2008 - Elsevier
Background: Sex hormones play a significant role in human physiology. Estrogen may have
protective effects in the cardiovascular system, as evidenced by the decreased incidence of …

Mechanistic pathways of sex differences in cardiovascular disease

V Regitz-Zagrosek, G Kararigas - Physiological reviews, 2016 - journals.physiology.org
Major differences between men and women exist in epidemiology, manifestation,
pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as …