Stereoselective glucuronidation metabolism, pharmacokinetics, anti-amnesic pharmacodynamics, and toxic properties of vasicine enantiomers in vitro and in vivo

Y Zhu, W Liu, S Qi, H Wang, Y Wang, G Deng… - European Journal of …, 2018 - Elsevier
Vasicine (VAS) is a potential natural cholinesterase inhibitor for treatment of Alzheimer's
disease. Due to one chiral centre (C-3) presenting in molecule, VAS has two enantiomers, d …

Red blood cell acetylcholinesterase activity among healthy dwellers of an agrarian region in Sri Lanka: a descriptive cross-sectional study

D Rathish, I Senavirathna, C Jayasumana… - … Health and Preventive …, 2018 - Springer
Background Assessment of acetylcholinesterase-inhibitor insecticide (AChEII) toxicity
depends on the measurement of red blood cell acetylcholinesterase (RBC-AChE) activity. Its …

2-Aryl-3-(arylideneamino)-1, 2-dihydroquinazoline-4 (3 H)-ones as inhibitors of cholinesterases and self-induced β-amyloid (Aβ) aggregation: biological evaluations …

SD Sukumaran, FL Faraj, VS Lee, R Othman… - RSC …, 2018 - pubs.rsc.org
A series of 2-aryl-3-(arylideneamino)-1, 2-dihydroquinazoline-4 (3H)-ones were evaluated
as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and self …

Gene expressions, hippocampal volume loss, and MMSE scores in computation of progression and pharmacologic therapy effects for Alzheimer's disease

A Saribudak, AA Subick, NH Kim… - … /ACM transactions on …, 2018 - ieeexplore.ieee.org
We build personalized relevance parameterization method (pr e p-ad) based on artificial
intelligence (ai) techniques to compute Alzheimer's disease (ad) progression for patients at …

Beneficial Effects of Gagam‐Palmultang on Scopolamine‐Induced Memory Deficits in Mice

YR Kim, MY Kwon, ME Pak, SH Park… - Evidence‐Based …, 2018 - Wiley Online Library
From text mining of Dongeuibogam, the 7 herbs in Palmultang can be considered effective
candidates for memory enhancement. We sought to determine whether Gagam‐Palmultang …

Intramolecular cyclization of polyfluoroalkyl-containing 2-(arylhydrazinylidene)-1, 3-diketones

OG Khudina, EV Shchegol'kov, YV Burgart… - Journal of Fluorine …, 2018 - Elsevier
Abstract Refluxing of polyfluoroalkyl-containing 2-(arylhydrazinylidene)-1, 3-diketones in
dichloroalkanes in the presence of TiCl 4 gives 3-acyl-4-polyfluoroalkylcinnolines as a result …

Anti-amnesic effect and antioxidant defense systems of Yukmijihwang-tang on scopolamine-induced memory impairment in mice

YM Seo, D Han, S Kim, D Chung - Journal of Oriental …, 2018 - koreascience.kr
Objectives: The objective of this study was to observe the anti-amnesic effects of
Yukmijihwang-tang (YMJHT), on the scopolamine (Sco)-induced memory impairment in …

Anti-amnesic and Antioxidant Effect of Yeongkyekamjotanggayonggolmoryo Aqueous Extracts on Scopolamine-induced Memory Impairment in Mice

D Kim, D Han, S Kim, D Chung - Journal of Oriental …, 2018 - koreascience.kr
Objectives: The purpose of this in vivo study is to observe anti-amnesic effects of
Yeongkyekamjotanggayonggolmoryo (YGYM), a novel mixed herbal prescription, Ossis …

Natural Therapeutics for Alzheimer's Disease

S Dang, D Mehtani, A Kaur, R Gabrani - Functional Food and Human …, 2018 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease which is serious, persistent and
progressive and is linked with deterioration of memory and cognition. Commonly …

Synthesis and Characterisation of Novel Phenanthroline Quinone Derivatives and Their Evaluation as Alzheimer's Disease Therapeutic Active Ingredients

SA Tosonyan - 2018 - search.proquest.com
The study is based on the synthesis, characterisation and biological evaluation of series of
new derivatives of phen-5, 6-dione potentially could act as inhibitors for acetylcholinesterase …