Abstract ɷ-Conotoxin MVIIA (ziconotide or SNX-111) is an atypical analgesic drug with the
water-soluble formulation and routinely is injected into the brain and spinal regions in …

Pain is a sensory experience of a complex physiological nature in which is not only involved
the nervous system. Among its many features is the development of chronic pain that is more …

Inflammatory pain is a complex and multifactorial disorder. Apurinic/apyrimidinic
endonuclease 1 (APE1), also called Redox Factor-1 (Ref-1), is constitutively expressed in …

This work reports the purification of new potent scorpion neuropeptide, named BotAF, by an
activity-guided screening approach. BotAF is a 64-residue long-chain peptide that shares …

In DRG an increase in miR-133b-3p, miR-143-3p, and miR-1-3p correlates with the lack of
development of neuropathic pain following a peripheral nerve injury. Using lentiviral (LV) …

This study evaluates whether intrathecal MVIIA injection after spinal cord injury (SCI) elicits
neuroprotective effects. The test rats were randomly distributed into six groups—sham …

The central nervous system controls the innate immunity by modulating efferent neuronal
networks. Recently, we have reported that central brain stimulation inhibits inflammatory …

Neonatal handling (NH) of male rat pups strongly attenuates stress response and stress-
induced persistent muscle hyperalgesia in adults. Because female sex is a well established …

Objectives: To quantify transcriptional changes in AKAP150 expression and/or function after
long-term mGluR5 agonist exposure, and identify transcriptional elements responsible …

Objective To determine the role of anion exchanger 3 (AE3) in dorsal root ganglion (DRG) in
nerve injury-induced chronic nociception in the rat. Methods Spared nerve injury (SNI) was …