High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …

Importance The increasing burden due to cancer and other noncommunicable diseases
poses a threat to human development, which has resulted in global political commitments …

Background Lower respiratory infections are a leading cause of morbidity and mortality
around the world. The Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study …

Importance Rotavirus infection is the global leading cause of diarrhea-associated morbidity
and mortality among children younger than 5 years. Objectives To examine the extent of …

Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study
(GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor …

Background Early studies suggest that radiofrequency-based renal denervation reduces
blood pressure in patients with moderate hypertension. We investigated whether an …

Air pollution is a complex mixture of gaseous and particulate components, each of which has
detrimental effects on human health. While the composition of air pollution varies greatly …

Background Alcohol and drug use can have negative consequences on the health,
economy, productivity, and social aspects of communities. We aimed to use data from the …

Background The lifetime risk of stroke has been calculated in a limited number of selected
populations. We sought to estimate the lifetime risk of stroke at the regional, country, and …

A gap in emission inventories of urban volatile organic compound (VOC) sources, which
contribute to regional ozone and aerosol burdens, has increased as transportation …