Genome-wide association studies (GWAS) have been shown to have the potential of
explaining more of the “missing heritability” of complex human phenotypes by improving …

Previously, our comprehensive cardiovascular characterization study validated Uromodulin
as a blood pressure gene. Uromodulin is a glycoprotein exclusively synthesized at the thick …

Настоящее пособие предназначено, в первую очередь, для желающих поступить в
ТУСУР и для преподавателей осуществляющих их подготовку. Поскольку …

Background Nephrolithiasis is a worldwide health problem that affects almost all
populations. This study aimed to evaluate the association between rs12654812 of regulator …

Homo sapiens longevity assurance homolog 2 of yeast LAG1 (LASS2) is expressed mostly
in human liver. Here, we explored roles of LASS2 in pathogenesis of hepatic steatosis …

Background Despite the important role of the nerve growth factor in the survival and
maintenance of neurons in ischemic stroke, data regarding the relationships between …

The H19-IGF2 imprinted gene region could be implicated in the risk of developing impaired
renal function (IRF). Our aim was to determine the association of several common H19-IGF2 …

The genetic etiology of many complex diseases is highly heterogeneous. A complex disease
can be caused by multiple mutations within the same gene or mutations in multiple genes at …

This study aims to investigate whether renal and cardiovascular phenotypes in Italian
patients with type 2 diabetes (T2D) could be influenced by a number of disease risk SNPs …

FAM122A is a highly conserved protein in mammals. Here, we identify that FAM122A can be
sumoylated at lysine 89, which can be de-conjugated by SENP1. Furthermore, the …