Hedgehog (Hh) signaling is an essential pathway in the human body, and plays a major role
in embryo development and tissue patterning. Constitutive activation of the Hh signaling …

X-chromosome inactivation (XCI) provides a dosage compensation mechanism where, in
each female cell, one of the two X chromosomes is randomly silenced. However, some …

Brain tumors are the leading cause of cancer-related death in children, and
medulloblastoma (MB) is the most common malignant pediatric brain tumor. Advances in …

Medulloblastoma is the most frequent malignant childhood brain tumor with a high morbidity.
Identification of new therapeutic targets would be instrumental in improving patient …

Epigenetics is the process by which gene expression is regulated by events other than
alterations of the genome. This includes DNA methylation, histone modifications, chromatin …

Despite significant improvements in pediatric brain tumor therapy and outcome, too many
children still die of disease, and too many survivors experience significant sequelae as a …

Chromothripsis and chromoanasynthesis are catastrophic events leading to clustered
genomic rearrangements. Whole-genome sequencing revealed frequent complex genomic …

Background: Medulloblastoma is the most common malignant brain tumor in children,
currently treated uniformly based on histopathology and clinico-radiological risk stratification …

Background Germline mutations of suppressor of fused homolog (SUFU) predispose to
sonic hedgehog (SHH) medulloblastoma. Germline SUFU mutations have been reported in …

Adhesion G protein-coupled receptors (ADGRs) encompass 33 human transmembrane
proteins with long N termini involved in cell-cell and cell-matrix interactions. We show the …