Objective: It is known that ventilator-induced lung injury causes increased pulmonary
inflammation. It has been suggested that one of the underlying mechanisms may be strain …

Objective: The common denominator in most forms of ventilator-induced lung injury is an
intense inflammatory response mediated by neutrophils. PET with [18 F] fluoro-2-deoxy-D …

Objectives: To determine the impact of positive end-expiratory pressure during mechanical
ventilation with and without spontaneous breathing activity on regional lung inflammation in …

Rationale: The contribution of aeration heterogeneity to lung injury during early mechanical
ventilation of uninjured lungs is unknown. Objectives: To test the hypotheses that a strategy …

Objective: Tidal volume (VT) and volume of gas caused by positive end-expiratory pressure
(V PEEP) generate dynamic and static lung strains, respectively. Our aim was to clarify …

Objective: PET with [18 F] fluoro-2-deoxy-D-glucose can be used to image cellular
metabolism, which during lung inflammation mainly reflects neutrophil activity, allowing the …

Objective: Acute respiratory distress syndrome and acute lung injury are characterized by
heterogeneous flooding/collapse of lung tissue. An emerging concept for managing these …

Background Acute respiratory distress syndrome causes a heterogeneous lung injury with
normal and acutely injured lung tissue in the same lung. Improperly adjusted mechanical …

Background Protective mechanical ventilation (MV) aims at limiting global lung deformation
and has been associated with better clinical outcomes in acute respiratory distress …

Comparison of lung protective ventilation strategies in a ra... : Critical Care Medicine
Comparison of lung protective ventilation strategies in a rabbit model of acute lung injury …