Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas
cancer types from 8,705 patients detects alternative splicing events and tumor variants by …

Alternative splicing (AS) represents a crucial method in mRNA level to regulate gene
expression and contributes to the protein complexity. Abnormal splicing has been reported …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

Alternative splicing enhances proteome diversity and modulates cancer-associated proteins.
To identify tissue-and tumor-specific alternative splicing, we used the GeneChip Human …

The determination of the alternative splicing isoforms expressed in cancer is fundamental for
the development of tumor-specific molecular targets for prognosis and therapy, but it is …

A genome-wide computational screen was performed to identify tumor-associated
alternative RNA splicing isoforms. A BLAST algorithm was used to compare 11,014 genes …

Pre-messenger RNA splicing is a fine-tuned process that generates multiple functional
variants from individual genes. Various cell types and developmental stages regulate …

Background Somatic mutations affecting components of the RNA splicing machinery occur
with high frequencies across many tumor types. These mutations give rise to distinct …

Alternative splicing (AS) is a widespread process that increases structural transcript variation
and proteome diversity. Aberrant splicing patterns are frequently observed in cancer …

Background Collaborative projects such as The Cancer Genome Atlas (TCGA) have
generated various-omics and clinical data on cancer. Many computational tools have been …