Abnormally high production of melanin or melanogenesis in skin melanocytes results in
hyperpigmentation disorders, such as melasma, senile lentigines or freckles. These …

Human skin, eye and hair color rely on the production of melanin, depending on its quantity,
quality, and distribution, Melanin plays a monumental role in protecting the skin against the …

Melanins are pigment molecules that determine the skin, eye, and hair color of the human
subject to its amount, quality, and distribution. Melanocytes synthesize melanin and provide …

Highlights•Different melanogenesis signaling pathways.•Human tyrosinase inhibitors have
been discussed.•Drug repositioning has been applied to find new agents.Melanin, primarily …

Melanocytes are highly specialised dendritic cells that transfer melanin to keratinocytes in
subcellular lysosome-like organelles called melanosomes, where melanin is synthesised …

Melanogenesis is the process for the production of melanin, which is the primary cause of
human skin pigmentation. Skin‑whitening agents are commercially available for those who …

The occurrence of hyperpigmentation or hypopigmentation after inflammation is a common
condition in dermatology and cosmetology. Since the exact mechanism of its occurrence is …

Hyperpigmentation disorders constitute important medical and aesthetical conditions. Dark
areas or dark spots on the skin result from inappropriate amount and/or deposition of skin …

Few anti-pigmenting agents have been designed and developed according to their known
hyperpigmentation mechanisms and corresponding intracellular signaling cascades. Most …

Skin whitening products are commercially available for cosmetic purposes in order to obtain
a lighter skin appearance. They are also utilized for clinical treatment of pigmentary …