Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4–miR-18a pathway in cervical cancer

P Dong, Y Xiong, J Yu, L Chen, T Tao, S Yi… - Oncogene, 2018 - nature.com
PD-L1, a key inhibitory immune receptor, has crucial functions in cancer immune evasion,
but whether PD-L1 promotes the malignant properties of cervical cancer (CC) cells and the …

Circ_0000052/miR‐382‐3p axis induces PD‐L1 expression and regulates cell proliferation and immune evasion in head and neck squamous cell carcinoma

DJ Zhang, ZM Fu, YY Guo, F Guo… - Journal of Cellular …, 2023 - Wiley Online Library
A better understanding of the mechanisms underlying PD‐L1 aberrant expression in head
and neck squamous cell carcinoma (HNSCC) will help reveal predictive biomarkers and …

[HTML][HTML] PD-L1 expression correlates with tumor infiltrating lymphocytes and response to neoadjuvant chemotherapy in cervical cancer

Y Meng, H Liang, J Hu, S Liu, X Hao, MSK Wong… - Journal of …, 2018 - ncbi.nlm.nih.gov
Abstract Programmed death-ligand 1 (PD-L1) has been reported to be expressed in many
types of tumor cells, and bind to PD-1 on T lymphocytes to inhibit immune response …

[HTML][HTML] Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix

AM Heeren, S Punt, MCG Bleeker, KN Gaarenstroom… - Modern Pathology, 2016 - Elsevier
Abstract Programmed death-ligand 1 (PD-L1) is expressed in various immune cells and
tumor cells, and is able to bind to PD-1 on T lymphocytes, thereby inhibiting their function. At …

PD-L1 and PD-L2 expression in cervical cancer: regulation and biomarker potential

J Rotman, LAS Otter, MCG Bleeker… - Frontiers in …, 2020 - frontiersin.org
PD-1/PD-L1 immune checkpoint inhibitors show potential for cervical cancer treatment.
However, low response rates suggest that patient selection based on PD-L1 protein …

LINC00116 enhances cervical cancer tumorigenesis through miR‐106a/c‐Jun pathway

Y Lai, B Zhou, Q Tan, J Xu, T Wan… - Journal of Cellular …, 2020 - Wiley Online Library
Some studies imply that LINC00116 is involved in cervical cancer progression; however, the
molecular mechanism by which LINC00116 modulating tumorigenesis of cervical cancer …

miR-142-5p regulates tumor cell PD-L1 expression and enhances anti-tumor immunity

L Jia, Q Xi, H Wang, Z Zhang, H Liu, Y Cheng… - Biochemical and …, 2017 - Elsevier
Cancer immunotherapy has many great achievements in recent years. One of the most
promising cancer immunotherapies is PD-1/PD-L1 pathway blockade. miRNAs (MicroRNAs) …

[HTML][HTML] miR-375 inhibits IFN-γ-induced programmed death 1 ligand 1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 …

Q Wu, Y Zhao, Y Sun, X Yan… - Oncology …, 2018 - spandidos-publications.com
Upregulation of programmed death 1 ligand 1 (PD-L1) in cancer cells and its ligation to PD-
1 on T cells facilitates cancer cell escape from immune surveillance. Therapies with PD-1 or …

Elevated expression of programmed death‐1 and programmed death ligand‐1 negatively regulates immune response against cervical cancer cells

Z Chen, N Pang, R Du, Y Zhu, L Fan… - Mediators of …, 2016 - Wiley Online Library
The present study is to measure the expression of programmed death‐1 (PD‐1) and
programmed death ligand‐1 (PD‐L1), as well as its clinical significance in cervical cancer …

PD-1/PD-L1 axis regulation in cancer therapy: The role of long non-coding RNAs and microRNAs

M Ashrafizadeh, A Zarrabi, K Hushmandi, V Zarrin… - Life sciences, 2020 - Elsevier
Cancer immunotherapy is a growing field nowadays. Among different molecular pathways,
PD-1/PD-L1 signaling pathway plays a significant role in the regulation of immune …