Current therapeutic molecules and targets in neurodegenerative diseases based on in silico drug design

SA Sehgal, MA Hammad, RA Tahir… - Current …, 2018 - ingentaconnect.com
Background: As the number of elderly persons increases, neurodegenerative diseases are
becoming ubiquitous. There is currently a great need for knowledge concerning …

In silico studies in drug research against neurodegenerative diseases

FR Makhouri, JB Ghasemi - Current neuropharmacology, 2018 - ingentaconnect.com
Background: Neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic
lateral sclerosis, Parkinson's disease (PD), spinal cerebellar ataxias, and spinal and bulbar …

Application of in silico methods in the design of drugs for neurodegenerative diseases

M Haider, A Chauhan, S Tariq… - Current Topics in …, 2021 - ingentaconnect.com
Neurodegenerative diseases are complex disorders that cause neuron loss, brain aging and
ultimately lead to death. These diseases are difficult to treat because of the complex nature …

Recent developments in new therapeutic agents against Alzheimer and Parkinson diseases: in-silico approaches

P Cruz-Vicente, LA Passarinha, S Silvestre, E Gallardo - Molecules, 2021 - mdpi.com
Neurodegenerative diseases (ND), including Alzheimer's (AD) and Parkinson's Disease
(PD), are becoming increasingly more common and are recognized as a social problem in …

In silico studies applied to natural products with potential activity against Alzheimer's disease

L Scotti, MT Scotti - Computational modeling of drugs against Alzheimer's …, 2018 - Springer
The neurodegenerative disease, named Alzheimer's disease (AD) after its discoverer, is
today considered the most common form of dementia. AD represents 60–70% of dementia …

Combining in vitro and in silico approaches to find new candidate drugs targeting the pathological proteins related to the Alzheimer's disease

H Li, X Wang, H Yu, J Zhu, H Jin… - Current …, 2018 - ingentaconnect.com
Background: Alzheimer's disease (AD) as the most common cause of dementia among older
people has aroused the universal concern of the whole world. However, until now there is …

Phytochemicals for drug discovery in Alzheimer's disease: in silico advances

S Sharma, V Bhatia - Current Pharmaceutical Design, 2021 - ingentaconnect.com
The search for novel drugs that can prevent or control Alzheimer's disease has attracted a lot
of attention from researchers across the globe. Phytochemicals are increasingly being used …

[HTML][HTML] Computer aided drug design methodologies with natural products in the drug research against alzheimer's disease

NF de Sousa, L Scotti, ÉP de Moura… - Current …, 2022 - ncbi.nlm.nih.gov
Natural products are compounds isolated from plants that provide a variety of lead structures
for the development of new drugs by the pharmaceutical industry. The interest in these …

Advances in applying computer-aided drug design for neurodegenerative diseases

MM Salman, Z Al-Obaidi, P Kitchen, A Loreto… - International journal of …, 2021 - mdpi.com
Neurodegenerative diseases (NDs) including Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease are incurable and affect millions of …

Role of computational modeling in drug discovery for Alzheimer's disease

MR Yadav, PR Murumkar, R Barot, R Yadav… - Current Trends in …, 2023 - Springer
Researchers are striving hard for the last two decades to discover new therapeutically
effective molecules for the treatment of Alzheimer's disease (AD). Unfortunately, the exact …