Diverse roles for the ror‐family receptor tyrosine kinases in neurons and glial cells during development and repair of the nervous system

M Endo, Y Minami - Developmental Dynamics, 2018 - Wiley Online Library
The Ror‐family of receptor tyrosine kinases (RTKs) are involved critically in tissue genesis
and organogenesis during development. In mammals, Ror1 and Ror2, members of the Ror …

Critical role of Ror2 receptor tyrosine kinase in regulating cell cycle progression of reactive astrocytes following brain injury

M Endo, G Ubulkasim, C Kobayashi, R Onishi, A Aiba… - Glia, 2017 - Wiley Online Library
Ror2 receptor tyrosine kinase plays crucial roles in developmental morphogenesis and
tissue‐/organo‐genesis. In the developing brain, Ror2 is expressed in neural …

Expression and function of the Ror‐family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans

A Yoda, I Oishi, Y Minami - Journal of receptors and signal …, 2003 - Taylor & Francis
Receptor tyrosine kinases (RTKs) play crucial roles in various developmental processes.
Ror‐family RTKs are characterized by the intracellular tyrosine kinase domains, highly …

Ror1-Ror2 complexes modulate synapse formation in hippocampal neurons

S Paganoni, J Bernstein, A Ferreira - Neuroscience, 2010 - Elsevier
Ror1 and Ror2, a small family of tyrosine kinase receptors, have been implicated in multiple
aspects of brain development in C. elegans and X. laevis. More recently, we have shown …

Wnt signaling through the Ror receptor in the nervous system

IM Petrova, MJ Malessy, J Verhaagen, LG Fradkin… - Molecular …, 2014 - Springer
The receptor tyrosine kinase-like orphan receptor (Ror) proteins are conserved tyrosine
kinase receptors that play roles in a variety of cellular processes that pattern tissues and …

ROR2 homodimerization is sufficient to activate a neuronal Wnt/calcium signaling pathway

R Riquelme, L Li, A Gambrill, A Barria - Journal of Biological Chemistry, 2023 - ASBMB
Wnt signaling plays a key role in the mature CNS by regulating trafficking of NMDA-type
glutamate receptors and intrinsic properties of neurons. The Wnt receptor ROR2 has been …

Expression and subcellular localization of Ror tyrosine kinase receptors are developmentally regulated in cultured hippocampal neurons

S Paganoni, A Ferreira - Journal of neuroscience research, 2003 - Wiley Online Library
Ror1 and Ror2 are two novel receptor tyrosine kinases that have been implicated in
neuronal differentiation in Caenorhabditis elegans. As a first step toward elucidating their …

Ror‐family receptor tyrosine kinases in noncanonical Wnt signaling: Their implications in developmental morphogenesis and human diseases

Y Minami, I Oishi, M Endo… - … dynamics: an official …, 2010 - Wiley Online Library
The Ror‐family receptor tyrosine kinases (RTKs) play crucial roles in the development of
various organs and tissues. In mammals, Ror2, a member of the Ror‐family RTKs, has been …

Ror family receptor tyrosine kinases regulate the maintenance of neural progenitor cells in the developing neocortex

M Endo, R Doi, M Nishita, Y Minami - Journal of cell science, 2012 - journals.biologists.com
The Ror family receptor tyrosine kinases (RTKs), Ror1 and Ror2, have been shown to play
crucial roles in developmental morphogenesis by acting as receptors or co-receptors to …

Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains

TW Bainbridge, VI DeAlmeida, A Izrael-Tomasevic… - PloS one, 2014 - journals.plos.org
Receptor tyrosine kinase-like orphan receptors (ROR) 1 and 2 are atypical members of the
receptor tyrosine kinase (RTK) family and have been associated with several human …