Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

Mitochondria play a central role in a plethora of processes related to the maintenance of
cellular homeostasis and genomic integrity. They contribute to preserving the optimal …

Mitochondrial dysfunction plays a very vital role in the pathogenesis of Alzheimer's disease
(AD). Several shreds of evidence have indicated that the mitochondrial function is severely …

Many neurodegenerative diseases demonstrate abnormal mitochondrial morphology and
biochemical dysfunction. Alterations are often systemic rather than brain-limited …

Many lines of evidence suggest that mitochondria have a central role in ageing-related
neurodegenerative diseases. However, despite the evidence of morphological, biochemical …

Neurodegenerative diseases are a large group of disabling disorders of the nervous system,
characterized by the relative selective death of neuronal subtypes. In most cases, there is …

Mitochondrial dysfunction represents a well-established player in the pathogenesis of both
monogenic and idiopathic Parkinson's disease (PD). Initially originating from the observation …

Mitochondrial dysfunction has been reported in a wide array of neurological disorders
ranging from neuromuscular to neurodegenerative diseases. Recent studies on …

Mitochondria are implicated in several metabolic pathways including cell respiratory
processes, apoptosis, and free radical production. Mitochondrial abnormalities have been …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …