Due to the vast molecular complexity of skeletal muscle and the nervous system, it is
necessary to surmount certain obstacles to carry out systematic explorations and provide …

Introduction: Human skeletal muscle represents 40% of our body mass and deciphering its
proteome composition to further understand mechanisms regulating muscle function under …

Background Skeletal muscle fibres represent one of the most abundant cell types in
mammals. Their highly specialised contractile and metabolic functions depend on a large …

Over the last few decades of biomedical research, animal models of neuromuscular
diseases have been widely used for determining pathological mechanisms and for testing …

Skeletal muscle fibers are the most abundant cellular structure in the human body. Altered
neuromuscular activity, traumatic injury or genetic abnormalities have profound effects on …

Neuromuscular diseases with primary muscle wasting symptoms may also display multi-
systemic changes in the body and exhibit secondary pathophysiological alterations in …

One of the most striking physiological features of skeletal muscle tissues are their enormous
capacity to adapt to changed functional demands. Muscle plasticity has been extensively …

Voluntary striated muscles are characterized by a highly complex and dynamic proteome
that efficiently adapts to changed physiological demands or alters considerably during …

The accumulation in neurons of aberrant protein species, the pathological hallmark of many
neurodegenerative diseases, results from a global impairment of key cellular processes …

The fatal neurodegenerative disorders amyotrophic lateral sclerosis and spinal muscular
atrophy are, respectively, the most common motoneuron disease and genetic cause of infant …