Predicting peroxisomal targeting signals to elucidate the peroxisomal proteome of mammals

M Kunze - … of Peroxisomes: Identifying Novel Functions and …, 2018 - Springer
Peroxisomes harbor a plethora of proteins, but the peroxisomal proteome as the entirety of
all peroxisomal proteins is still unknown for mammalian species. Computational algorithms …

Identifying novel peroxisomal proteins

J Hawkins, D Mahony, S Maetschke… - Proteins: Structure …, 2007 - Wiley Online Library
Peroxisomes are small subcellular compartments responsible for a range of essential
metabolic processes. Efforts in predicting peroxisomal protein import are challenged by …

In silico prediction of the peroxisomal proteome in fungi, plants and animals

O Emanuelsson, A Elofsson, G von Heijne… - Journal of molecular …, 2003 - Elsevier
In an attempt to improve our abilities to predict peroxisomal proteins, we have combined
machine-learning techniques for analyzing peroxisomal targeting signals (PTS1) with …

A Systematic Cell‐Based Analysis of Localization of Predicted Drosophila Peroxisomal Proteins

MN Baron, CM Klinger, RA Rachubinski, AJ Simmonds - Traffic, 2016 - Wiley Online Library
Peroxisomes are membrane‐bound organelles found in almost all eukaryotic cells. They
perform specialized biochemical functions that vary with organism, tissue or cell type …

Predicted mouse peroxisome-targeted proteins and their actual subcellular locations

Y Mizuno, IV Kurochkin, M Herberth, Y Okazaki… - Bmc Bioinformatics, 2008 - Springer
Background The import of most intraperoxisomal proteins is mediated by peroxisome
targeting signals at their C-termini (PTS1) or N-terminal regions (PTS2). Both signals have …

Defining the mammalian peroxisomal proteome

E Yifrach, S Fischer, S Oeljeklaus, M Schuldiner… - … Novel Functions and …, 2018 - Springer
The current view on peroxisomes has changed dramatically from being human cell oddities
to vital organelles that host several key metabolic pathways. To fulfil over 50 different …

Sequence-based discovery of the human and rodent peroxisomal proteome

IV Kurochkin, T Nagashima, A Konagaya… - Applied …, 2005 - Springer
Background: Peroxisomes are metabolic organelles present in virtually all eukaryotic cells.
They contain enzymes involved in hydrogen peroxide-based respiration and lipid …

The obvious and the hidden: Prediction and function of fungal peroxisomal matrix proteins

J Freitag, T Stehlik, AC Stiebler, M Bölker - Proteomics of Peroxisomes …, 2018 - Springer
Fungal peroxisomes are characterized by a number of specific biological functions. To
understand the physiology and biochemistry of these organelles knowledge of the proteome …

In-pero: Exploiting deep learning embeddings of protein sequences to predict the localisation of peroxisomal proteins

M Anteghini, V Martins dos Santos… - International Journal of …, 2021 - mdpi.com
Peroxisomes are ubiquitous membrane-bound organelles, and aberrant localisation of
peroxisomal proteins contributes to the pathogenesis of several disorders. Many …

PeroxisomeDB: a database for the peroxisomal proteome, functional genomics and disease

A Schlüter, S Fourcade… - Nucleic acids …, 2007 - academic.oup.com
Peroxisomes are essential organelles of eukaryotic origin, ubiquitously distributed in cells
and organisms, playing key roles in lipid and antioxidant metabolism. Loss or malfunction of …