With the increase in the number of long‐term cancer survivors worldwide, there is a growing
concern about the risk of secondary cancers induced by radiotherapy. Epigenetic …

Several lines of evidence indicate one's age at exposure to radiation strongly modifies the
risk of radiation-induced breast cancer. We previously reported that rat mammary …

Purpose: Ionizing radiation is a potent mammary gland carcinogen, yet the exact molecular
etiology of radiation-induced breast cancer remains unknown. Materials and methods: Our …

Background Breast tissue is among the most sensitive tissues to the carcinogenic actions of
ionizing radiation and epidemiological studies have linked radiation exposure to breast …

Radiation-Induced CardioVascular Disease (RICVD) is an important concern in thoracic
radiotherapy with complex underlying pathophysiology. Recently, we proposed DNA …

To identify epigenetically-regulated genes in breast cancer, MCF-7 cells were exposed to
250nM 5-aza or 5-aza+ 50nM TSA for 3 weeks followed by a 5 week recovery period after …

Background Exposure to ionizing radiation (IR) results in the simultaneous activation or
downregulation of multiple signaling pathways that play critical roles in cell type-specific …

Breast cancer has been considered to be a multifactorial disease with a wide array of well-
characterized gene mutations and chromosomal abnormalities. However, it is becoming …

Malignant breast cancer remains a major health threat to women of all ages worldwide and
epigenetic variations on DNA methylation have been widely reported in cancers of different …

DNA methylation can regulate gene expression and has been shown to modulate cancer
cell biology and chemotherapy resistance. Therapeutic radiation results in a biological …