Objective This systematic review provided a critical synthesis and a comprehensive
overview of guidelines on the treatment of mixed states. Method The MEDLINE/PubMed and …

Objective: Mixed episodes comprise up to 40% of acute bipolar admissions. They are
difficult‐to‐treat, complex clinical pictures. This review provides an overview of the available …

Objectives. We reviewed the treatment of bipolar mixed states using efficacy data of licensed
and non-licensed physical or pharmacological treatments. Methods. We conducted a …

Objective: Mixed states in affective disorders represent a particular challenge in clinical
routine, characterized by a complicated course of treatment and a worse treatment …

Mixed bipolar states are associated with more severe symptoms and outcome. Our aim is to
review the literature examining their treatment. We conducted a literature search of …

Approximately 40% of patients with bipolar disorder experience mixed episodes, defined as
a manic state with depressive features, or manic symptoms in a patient with bipolar …

Abstract Purpose of Review Mixed presentations in bipolar disorder have long posed clinical
and nosological challenges. The DSM-5 mixed features specifier was developed to provide …

Bipolar mixed states remain a nosologic dilemma, diagnostic challenge and neglected area
of therapeutic research. While the outcome of mixed states is generally poorer than that of …

Abstract Objectives The 2018 Canadian Network for Mood and Anxiety Treatments
(CANMAT) and International Society for Bipolar Disorders (ISBD) guidelines provided …

Mixed states in bipolar disorder have been neglected, and the data concerning treatment of
these conditions have been relatively obscure. To address this, we systematically reviewed …