Comparative metabolomics of aging in a long-lived bat: Insights into the physiology of extreme longevity

HC Ball, S Levari-Shariati, LN Cooper, M Aliani - PLoS One, 2018 - journals.plos.org
Vespertilionid bats (Mammalia: Order Chiroptera) live 3–10 times longer than other
mammals of an equivalent body size. At present, nothing is known of how bat fecal …

Bats and birds: exceptional longevity despite high metabolic rates

J Munshi-South, GS Wilkinson - Ageing research reviews, 2010 - Elsevier
Bats and birds live substantially longer on average than non-flying mammals of similar body
size. The combination of small body size, high metabolic rates, and long lifespan in bats and …

Longitudinal comparative transcriptomics reveals unique mechanisms underlying extended healthspan in bats

Z Huang, CV Whelan, NM Foley, D Jebb… - Nature ecology & …, 2019 - nature.com
Bats are the longest-lived mammals, given their body size. However, the underlying
molecular mechanisms of their extended healthspans are poorly understood. To address …

Why do bats live so long?—Possible molecular mechanisms

FA Lagunas-Rangel - Biogerontology, 2020 - Springer
Contrasting with several theories of ageing, bats are mammals with remarkable longevity
despite their high metabolic rate, living on average three times more than other mammals of …

Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii

I Seim, X Fang, Z Xiong, AV Lobanov, Z Huang… - Nature …, 2013 - nature.com
Bats account for one-fifth of mammalian species, are the only mammals with powered flight,
and are among the few animals that echolocate. The insect-eating Brandt's bat (Myotis …

Ageing studies on bats: a review

AK Brunet-Rossinni, SN Austad - Biogerontology, 2004 - Springer
Bat biologists have long known about the exceptional longevity of bats (Order: Chiroptera),
which is unusual for mammals of such a small size and a high metabolic rate. Yet relatively …

Growing old, yet staying young: the role of telomeres in bats' exceptional longevity

NM Foley, GM Hughes, Z Huang, M Clarke, D Jebb… - Science …, 2018 - science.org
Understanding aging is a grand challenge in biology. Exceptionally long-lived animals have
mechanisms that underpin extreme longevity. Telomeres are protective nucleotide repeats …

[HTML][HTML] Genetic variation between long-lived versus short-lived bats illuminates the molecular signatures of longevity

Z Huang, CV Whelan, D Dechmann… - Aging (Albany NY …, 2020 - ncbi.nlm.nih.gov
Bats are the longest-lived mammals given their body size with majority of species exhibiting
exceptional longevity. However, there are some short-lived species that do not exhibit …

Life history, ecology and longevity in bats

GS Wilkinson, JM South - Aging cell, 2002 - Wiley Online Library
The evolutionary theory of aging predicts that life span should decrease in response to the
amount of mortality caused by extrinsic sources. Using this prediction, we selected six life …

Metabolomics of aging in primary fibroblasts from small and large breed dogs

PS Brookes, AG Jimenez - GeroScience, 2021 - Springer
Among several animal groups (eutherian mammals, birds, reptiles), lifespan positively
correlates with body mass over several orders of magnitude. Contradicting this pattern are …