Importance Older age, high levels of β-amyloid (Aβ), and the presence of the apolipoprotein
E (APOE) ε4 allele are risk factors for Alzheimer disease (AD). However, the extent to which …

The apolipoprotein E (APOE) ɛ4 allele and high levels of beta-amyloid (Aβ) are associated
with episodic memory decline and risk for Alzheimer's disease. However, there is debate …

Objective: To examine whether β-amyloid (Aβ) and APOE ε4 status independently contribute
or interact to influence longitudinal cognitive decline in clinically normal older individuals …

Importance Although the most common recent approach in Alzheimer disease drug
discovery is to directly target the β-amyloid (Aβ) pathway, the high prevalence of …

Introduction Our objective was to investigate the effect of sex on cognitive decline within the
context of amyloid β (Aβ) burden and apolipoprotein E genotype. Methods We analyzed sex …

Importance The Anti-Amyloid Treatment in Asymptomatic Alzheimer disease (A4) Study is an
ongoing prevention trial in clinically normal older individuals with evidence of elevated brain …

BACKGROUND AND PURPOSE: Age and the apolipoprotein E ε4 allele are well-known risk
factors for Alzheimer disease, but whether female sex is also a risk factor remains …

Importance Typical cognitive aging may be defined as age-associated changes in cognitive
performance in individuals who remain free of dementia. Ideally, the full adult age spectrum …

Objective The ε4 allele of apolipoprotein E (APOE) is the strongest known common genetic
risk factor for Alzheimer's disease (AD) and alters age of onset in retrospective studies. Here …

Background Only one study has investigated the relationship between cerebral β-amyloid
(Aβ), apolipoprotein E (APOE) ɛ4 genotype, and cognition. Although significant …