Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury

S Fakhri, L Dargahi, F Abbaszadeh, M Jorjani - Brain research bulletin, 2018 - Elsevier
Spinal cord injury (SCI) is a debilitating condition in which inflammatory responses in the
secondary phase of injury leads to long lasting sensory-motor dysfunction. The medicinal …

Anti-inflammatory and antioxidant effects of astaxanthin following spinal cord injury in a rat animal model

A Masoudi, M Jorjani, M Alizadeh… - Brain research …, 2021 - Elsevier
Spinal cord injury (SCI) is a severely debilitating problem leading to substantial decrease in
the quality of life. After spinal cord injury, inflammation and oxidative stress plays a key role …

Effects of astaxanthin on sensory‐motor function in a compression model of spinal cord injury: involvement of ERK and AKT signalling pathway

S Fakhri, L Dargahi, F Abbaszadeh… - European Journal of …, 2019 - Wiley Online Library
Background Spinal cord injury (SCI) causes continuous neurological deficits and major
sensory‐motor impairments. There is no effective treatment to enhance sensory‐motor …

Neuroprotective effects of astaxanthin in a rat model of spinal cord injury

A Masoudi, L Dargahi, F Abbaszadeh… - Behavioural brain …, 2017 - Elsevier
Spinal cord injury (SCI) often leads to constant neurological deficits and long-term
unalterable disability. Apoptosis plays an important role in the initiation of the secondary …

Astaxanthin ameliorates spinal cord edema and astrocyte activation via suppression of HMGB1/TLR4/NF-κB signaling pathway in a rat model of spinal cord injury

F Abbaszadeh, M Jorjani, MT Joghataei… - Naunyn-Schmiedeberg's …, 2023 - Springer
Spinal cord edema is a quick-onset phenomenon with long-term effects. This complication is
associated with inflammatory responses, as well as poor motor function. No effective …

[HTML][HTML] Astaxanthin alleviates spinal cord ischemia-reperfusion injury via activation of PI3K/Akt/GSK-3β pathway in rats

J Fu, H Sun, H Wei, M Dong, Y Zhang, W Xu… - Journal of Orthopaedic …, 2020 - Springer
Background Ischemia-reperfusion injury of the spinal cord (SCII) often leads to unalterable
neurological deficits, which may be associated with apoptosis induced by oxidative stress …

[HTML][HTML] Astaxanthin alleviates neuropathic pain by inhibiting the MAPKs and NF-κB pathways

L Zhao, X Tao, T Song - European journal of pharmacology, 2021 - Elsevier
Neuropathic pain is a complex condition that usually lasts a lifetime and has a major
negative impact on life after injury. Improving pain management is an important and unmet …

Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1/NRF2/Prx2/ASK1/p38 after traumatic brain injury in mice

XS Zhang, Y Lu, W Li, T Tao, L Peng… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Oxidative stress and neuronal apoptosis play key roles in
traumatic brain injury. We investigated the protective effects of astaxanthin against traumatic …

[HTML][HTML] Astaxanthin alleviates cerebral edema by modulating NKCC1 and AQP4 expression after traumatic brain injury in mice

M Zhang, Z Cui, H Cui, Y Cao, Y Wang, C Zhong - BMC neuroscience, 2016 - Springer
Background Astaxanthin is a carotenoid pigment that possesses potent antioxidative, anti-
inflammatory, antitumor, and immunomodulatory activities. Previous studies have …

[HTML][HTML] The putative role of astaxanthin in neuroinflammation modulation: Mechanisms and therapeutic potential

S Wang, X Qi - Frontiers in Pharmacology, 2022 - frontiersin.org
Neuroinflammation is a protective mechanism against insults from exogenous pathogens
and endogenous cellular debris and is essential for reestablishing homeostasis in the brain …