The aim of this study was to evaluate changes in the expression of cannabinoid type 1 (CB1)
and 2 (CB2) receptor proteins in several brain regions in rats undergoing cocaine self …

Acute rewarding properties are essential for the establishment of cocaine addiction, and
multiple neurochemical processes participate in this complex behavior. In the present study …

The discovery of functional cannabinoid receptors 2 (CB 2 Rs) in brain suggests a potential
new therapeutic target for neurological and psychiatric disorders. However, recent findings …

The potential involvement of the cannabinoid CB 2 receptors (CB 2 r) in the adaptive
responses induced by cocaine was studied in transgenic mice overexpressing the CB 2 r …

CB1 cannabinoid receptor agonists show a different profile compared to other drugs of
abuse on the basis of experimental data that reveal their reinforcing properties. Thus, there …

The endogenous cannabinoid system is a relatively novel discovered system consisting of
cannabinoid CB1 receptors, which are expressed both in the periphery and in the central …

Background: Studies have shown the involvement of cannabinoid (CB) receptors in the
behavioral and neurobiological effects of psychostimulants. Most of these studies have …

The effect of the CB1 cannabinoid receptor agonist WIN 55, 212-2 on intravenous cocaine
self-administration (IVSA) in rats was evaluated. Male Long Evans rats were implanted with …

Recent evidence suggest that the endocannabinoid system might be a component of the
brain reward system and, then, play a role, not only in cannabinoid tolerance/dependence …

Rationale Cocaine is a psychostimulant drug that facilitates monoaminergic
neurotransmission. The endocannabinoid system, comprising the cannabinoid receptors …