Incomplete understanding of the metastatic process hinders personalized therapy. Here we
report the most comprehensive whole-genome study of colorectal metastases vs. matched …

In contrast to primary colorectal cancer (CRC) little is known about the genomic landscape of
metastasized CRC. Here we present whole genome sequencing data of metastases of 429 …

Colorectal cancer (CRC) patients have poor prognosis after formation of distant metastasis.
Understanding the molecular mechanisms by which genetic changes facilitate metastasis is …

Introduction Metastasis is thought to be a clonal event whereby a single cell initiates the
development of a new tumor at a distant site. However the degree to which primary and …

Both the timing and molecular determinants of metastasis are unknown, hindering treatment
and prevention efforts. Here we characterize the evolutionary dynamics of this lethal process …

Metastasis is a complex biological process that has been difficult to delineate in human
colorectal cancer (CRC) patients. A major obstacle in understanding metastatic lineages is …

Background Colorectal cancer is the second leading cause of cancer death in the United
States, with over 50,000 deaths estimated in 2014. Molecular profiling for somatic mutations …

Objective The systemic spread of colorectal cancer (CRC) is dominated by the portal system
and exhibits diverse patterns of metastasis without systematical genomic investigation. Here …

Colorectal cancer is driven by the accumulation of driver mutations, but the contributions of
specific mutations to different steps in malignant progression are not fully understood. In this …

Background Distant metastasis accounts for 90% of deaths from colorectal cancer (CRC).
Genomic heterogeneity has been reported in various solid malignancies, but remains …