Genomic sequencing has undergone massive expansion in the past 10 yr, from a rarely
used research tool into an approach that has broad applications in a clinical setting. From …

The price of whole-genome and-exome sequencing has fallen to the point where these
methods can be applied to clinical medicine. Here, we outline the lessons we have learned …

The completion of draft sequences of the human genome represented a remarkable
achievement for automated DNA sequencing based on Sanger technology. However, the …

Following the “finished,” euchromatic, haploid human reference genome sequence, the
rapid development of novel, faster, and cheaper sequencing technologies is making …

Eleven years since the initial drafts of the human genome were published, we have begun to
see the first examples of the application of whole‐genome sequencing to personalized …

The completion of the first draft of the Human Genome Project in 2001, and subsequent
refinements since then, have stimulated an explosion of research about the human genome …

Adoption of whole-genome sequencing as a routine biomedical tool is dependent not only
on the availability of new high-throughput sequencing technologies, but also on the …

The finished sequence of the Human Genome Project, published 50 years after Watson and
Crick's seminal paper on the structure of DNA, pushed human genetics into the public eye …

Next-generation sequencing technologies have greatly lowered the cost of whole-genome
sequencing (WGS) and related approaches. Thus, comprehensive sequencing for …

THE PAST 60 YEARS HAVE WITNESSED REMARKABLE progress in genetics and
genomics from the descrip-tion of the DNA double helix by Watson and Crick1 to the release …