Early endosomes are organelles that receive macromolecules and solutes from the
extracellular environment. The major function of early endosomes is to sort these cargos into …

Abnormally enlarged early endosomes (EEs) are pathological features of
neurodegenerative diseases, yet insight into the mechanisms and consequences of EE …

Endocytosis is universally important in cell function. In the brain, the roles of endosomes are
relatively more complex due to the unique polar morphology of neurons and specialized …

The early endosome is the first vacuolar compartment along the endocytic pathway. It is the
site of internalization and initial processing of amyloid precursor protein (APP) and …

Endocytosis marks the entry of internalized receptors into the complex network of endocytic
trafficking pathways. Endocytic vesicles are rapidly targeted to a distinct membrane-bound …

Membrane trafficking pathways, like the endocytic pathway, carry out fundamental cellular
processes that are essential for normal functioning. One such process is regulation of cell …

Efficient sorting of the material internalized by endocytosis is essential for key cellular
functions and represents a, if not the, major trafficking pathway in mammalian cells …

The endosomal-lysosomal system is made up of a set of intracellular membranous
compartments that dynamically interconvert, which is comprised of early endosomes …

The retinal pigmented epithelium (RPE) constitutes the outer blood‐retinal barrier, enables
photoreceptor function of the eye, and is constantly exposed to oxidative stress. As such …

The timely and efficient elimination of aberrant proteins and damaged organelles, formed in
response to various genetic and environmental stressors, is a vital need for all cells of the …