Rationale: In acute respiratory distress syndrome (ARDS), atelectatic solid-like lung tissue
impairs transmission of negative swings in pleural pressure (Ppl) that result from …

Rationale: Spontaneous breathing during mechanical ventilation increases transpulmonary
pressure and Vt, and worsens lung injury. Intuitively, controlling Vt and transpulmonary …

Rationale: In normal lungs, local changes in pleural pressure (Ppl) are generalized over the
whole pleural surface. However, in a patient with injured lungs, we observed (using …

Background In the acute respiratory distress syndrome (ARDS), positive end-expiratory
pressure (PEEP) may decrease ventilator-induced lung injury by keeping lung regions open …

Objectives: We recently described how spontaneous effort during mechanical ventilation can
cause “pendelluft,” that is, displacement of gas from nondependent (more recruited) lung to …

Rationale: The effects of high positive end-expiratory pressure (PEEP) strictly depend on
lung recruitability, which varies widely during acute respiratory distress syndrome (ARDS) …

Objectives: The benefits of spontaneous breathing over muscle paralysis have been proven
mainly in mild lung injury; no one has yet evaluated the effects of spontaneous breathing in …

Positive end-expiratory pressure (PEEP) is routinely applied in mechanically ventilated
patients to improve gas exchange and respiratory mechanics by increasing end-expiratory …

Objective: We investigated whether potentially injurious transpulmonary pressure could be
generated by strong spontaneous breathing and exacerbate lung injury even when plateau …

Rationale: Positive end-expiratory pressure (PEEP) and prone positioning may induce lung
recruitment and affect alveolar dynamics in acute respiratory distress syndrome (ARDS) …