We previously established the contribution of de novo damaging sequence variants to
Tourette disorder (TD) through whole-exome sequencing of 511 trios. Here, we sequence …

Whole-exome sequencing (WES) and de novo variant detection have proven a powerful
approach to gene discovery in complex neurodevelopmental disorders. We have completed …

Tourette's syndrome (TS) is a developmental disorder that has one of the highest familial
recurrence rates among neuropsychiatric diseases with complex inheritance. However, the …

Objective: Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly
heritable neurodevelopmental disorders that are thought to share genetic risk factors …

Abstract Georges Gilles de la Tourette, in describing the syndrome that now bears his name,
observed that the condition aggregated within families. Over the last three decades …

Objective Obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) are heritable
neurodevelopmental disorders with a partially shared genetic etiology. This study represents …

Background Tourette syndrome (TS) is often found comorbid with other neurodevelopmental
disorders across the impulsivity-compulsivity spectrum, with attention-deficit/hyperactivity …

Gilles de la Tourette Syndrome (TS) is a childhood-onset neurodevelopmental disorder that
is characterized by multiple motor and phonic tics. It has a complex etiology with multiple …

BACKGROUND: Studies of copy number variation (CNV) have characterized loci and
molecular pathways in a range of neuropsychiatric conditions. We analyzed rare CNVs in …

Background Genome-wide association studies have not revealed any risk-conferring
common genetic variants in Tourette syndrome (TS), requiring the adoption of alternative …