Objective A decreased plasma high density lipoprotein (HDL) cholesterol level is a strong
risk factor for coronary artery disease (CAD). Antioxidant activity of HDL mainly lies in the …

Background: The relation has not been reported consistently between the PON1 Q192R
polymorphism and coronary heart disease (CHD). To clarify the discrepancy, we performed …

Background Several meta-analyses have demonstrated that the rs662 polymorphism in
Paraoxonase 1 gene (PON1) gene is associated with coronary heart disease (CHD) …

BACKGROUND: Familial hypercholesterolemia (FH) is an autosomal dominant condition
characterized by abnormal levels of low-density lipoprotein (LDL) in the blood. FH is a risk …

Background The present study evaluated the role of the PON1 L55M polymorphism
independently and in conjunction with the Q192R polymorphism on the risk of coronary …

Background The oxidative modification of low-density lipoprotein in the artery wall is
currently believed to be central to the pathogenesis of atherosclerosis. Paraoxonase …

Paraoxonase is an enzyme associated with the high-density lipoprotein (HDL) particle. It
catalyses the hydrolysis of organophosphates and protects LDL from oxidative modification …

The paraoxonase (PON) gene family contains at least three members: PON1, PON2, and
PON3. The enzyme PON1 has been implicated in the pathogenesis of atherosclerosis …

Abstract Paraoxonase-1 (PON1) is a HDL-bound antioxidant enzyme that protects LDL from
oxidative modification. Discovery of the antioxidant properties of PON1 led to extensive …

OBJECTIVE: We tested the association between PON1 polymorphism, PON1 activity,
oxidative susceptibility of LDL and coronary artery disease in Egyptians. METHODS: PON1 …