[HTML][HTML] Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine …
A Fujita, H Yamaguchi, R Yamasaki, Y Cui… - Journal of …, 2018 - Springer
Background The first pathology observed in Parkinson's disease (PD) is 'dying back'of
striatal dopaminergic (DA) terminals. Connexin (Cx) 30, an astrocytic gap junction protein, is …
striatal dopaminergic (DA) terminals. Connexin (Cx) 30, an astrocytic gap junction protein, is …
Specific deletion connexin43 in astrocyte ameliorates cognitive dysfunction in APP/PS1 mice
R Ren, L Zhang, M Wang - Life sciences, 2018 - Elsevier
Emerging data indicate an important role for connexin43 (Cx43) in cognitive function, but
there is a lack of direct evidence of the role of astroglial Cx43 in cognitive dysfunction in …
there is a lack of direct evidence of the role of astroglial Cx43 in cognitive dysfunction in …
Modulation of connexin 43 in rotenone-induced model of Parkinson's disease
A Kawasaki, T Hayashi, K Nakachi, JE Trosko… - Neuroscience, 2009 - Elsevier
Gap junctional communication plays an important role in various models of brain pathology,
but the changes of gap junctions in Parkinsonism are still not understood. In this study, we …
but the changes of gap junctions in Parkinsonism are still not understood. In this study, we …
Connexin 43 deletion in astrocytes promotes CNS remyelination by modulating local inflammation
T Li, J Niu, G Yu, P Ezan, C Yi, X Wang, A Koulakoff… - Glia, 2020 - Wiley Online Library
As the most abundant gap junction protein in the central nervous system (CNS), astrocytic
connexin 43 (Cx43) maintains astrocyte network homeostasis, affects oligodendroglial …
connexin 43 (Cx43) maintains astrocyte network homeostasis, affects oligodendroglial …
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's …
Chronic microglial activation has been linked to the progressive degeneration of the
nigrostriatal dopaminergic neurons evidenced in Parkinson's disease (PD) pathogenesis …
nigrostriatal dopaminergic neurons evidenced in Parkinson's disease (PD) pathogenesis …
[HTML][HTML] Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson's Disease
I García-Domínguez, K Veselá… - Frontiers in cellular …, 2018 - frontiersin.org
The impact of systemic inflammation in nigral dopaminergic cell loss remains unclear. Here,
we have investigated the role of peripheral inflammation induced by systemic …
we have investigated the role of peripheral inflammation induced by systemic …
[HTML][HTML] Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity
L Maatouk, C Yi, MA Carrillo-de Sauvage… - Cell Death & …, 2019 - nature.com
The precise contribution of astrocytes in neuroinflammatory process occurring in Parkinson's
disease (PD) is not well characterized. In this study, using GRCx30CreERT2 mice that are …
disease (PD) is not well characterized. In this study, using GRCx30CreERT2 mice that are …
[HTML][HTML] Expression of Tgfβ1 and inflammatory markers in the 6-hydroxydopamine mouse model of Parkinson's disease
SJP Haas, X Zhou, V Machado, A Wree… - Frontiers in molecular …, 2016 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by loss of
midbrain dopaminergic (mDA) neurons in the substantia nigra (SN). Microglia-mediated …
midbrain dopaminergic (mDA) neurons in the substantia nigra (SN). Microglia-mediated …
[HTML][HTML] Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic …
ML Neal, SM Fleming, KM Budge… - … : official publication of …, 2020 - ncbi.nlm.nih.gov
Increased pro-inflammatory cytokine levels and proliferation of activated microglia have
been found in Parkinson's disease (PD) patients and animal models of PD, suggesting that …
been found in Parkinson's disease (PD) patients and animal models of PD, suggesting that …
[HTML][HTML] Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice
W Qu, A Johnson, JH Kim, A Lukowicz… - Journal of …, 2017 - Springer
Background Polyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes
spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative …
spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative …