Antidepressant drugs are currently one of the most prescribed medications. In addition to
treatment resistance and side effects of antidepressants, their clinical use is further …

Objective Antidepressants are at best 50–55% effective. Non‐compliance and the
antidepressant discontinuation syndrome (ADS) are causally related yet poorly appreciated …

Antidepressant drugs are prescribed to patients with depressive, anxiety disorders, and
other conditions. Evidence about antidepressant discontinuation syndrome (ADS) and …

Monoamine uptake inhibitors are common treatments for depression; however, the
therapeutic efficacy of these drugs varies widely. Two factors that are commonly linked to …

Besides demonstrated efficacy, selective serotonin reuptake inhibitors (SSRIs) hold other
advantages over earlier antidepressants such as greater tolerability and a wider range of …

Depression is one of the most frequent and severe mental disorder. Since the discovery of
antidepressant (AD) properties of the imipramine and then after of other tricyclic compounds …

Depression is a polygenic and highly complex psychiatric disorder that is currently a major
burden on society. Depression is highly heterogeneous in presentation and frequently …

This review discusses recent research of mood disorders associated with the cessation of
psychoactive substances, with an emphasis on preclinical studies that have been published …

Depression leads the higher personal and socio-economical burden within psychiatric
disorders. Despite the fact that over 40 antidepressants (ADs) are available, suboptimal …

Stopping antidepressants can be challenging due to the high rate of discontinuation
symptoms. Patients with antidepressant discontinuation syndrome (ADS) commonly …