In the absence of a more effective vaccine against TB and in the interest of developing one,
it is essential to understand immune responses associated with BCG protection. We …

BACKGROUND: In most tuberculosis (TB) endemic countries, bacillus Calmette–Guérin
(BCG) is usually given around birth to prevent severe TB in infants. The neonatal immune …

Vaccines to protect against tuberculosis (TB) are urgently needed. We performed a case–
control analysis to identify immune correlates of TB disease risk in Bacille Calmette–Guerin …

Background. Improved vaccination strategies against tuberculosis are needed, such as
approaches to boost immunity induced by the current vaccine, BCG. Design of these …

Background Mycobacterium bovis BCG vaccine has displayed inconsistent efficacy in
different trials conducted in various geographical regions. Nevertheless, it significantly …

Background Although BCG vaccination is recommended in most countries of the world, little
is known of the persistence of BCG-induced immune responses. As novel TB vaccines may …

Background. BCG vaccination prevents disseminated tuberculosis in children, but it is
contraindicated for persons with human immunodeficiency virus (HIV) infection because it …

BCG vaccine drives a strong T helper 1 cellular immunity which is essential for the protection
against mycobacteria, however recent studies suggest that BCG vaccination can have non …

BACKGROUND: The protective effect of Mycobacterium bovis BCG vaccination against
infection and atopy varies between populations. OBJECTIVE: To identify differences in …

BCG vaccination is known to induce innate immune memory, which confers protection
against heterologous infections. However, the effect of BCG vaccination on the conventional …