Regional amyloid accumulation and cognitive decline in initially amyloid-negative adults
Objective To assess whether global or regional changes in amyloid burden over 4 years
predict early declines in episodic memory in initially amyloid-negative adults. Methods One …
predict early declines in episodic memory in initially amyloid-negative adults. Methods One …
Memory decline accompanies subthreshold amyloid accumulation
Objective Extensive cortical β-amyloid (Aβ positivity) has been linked to cognitive decline,
but the clinical significance of elevations in Aβ within the negative range is unknown …
but the clinical significance of elevations in Aβ within the negative range is unknown …
Amyloid deposition in younger adults is linked to episodic memory performance
Objective: To examine the relationship of β-amyloid (Aβ) deposition to episodic memory in
younger (30–49 years), middle-older (50–69 years), and older adults (70–89 years). We …
younger (30–49 years), middle-older (50–69 years), and older adults (70–89 years). We …
Predicting symptom onset in sporadic Alzheimer disease with amyloid PET
SE Schindler, Y Li, VD Buckles, BA Gordon… - Neurology, 2021 - AAN Enterprises
Background and Objectives To predict when cognitively normal individuals with brain
amyloidosis will develop symptoms of Alzheimer disease (AD). Methods Brain amyloid …
amyloidosis will develop symptoms of Alzheimer disease (AD). Methods Brain amyloid …
Subthreshold amyloid predicts tau deposition in aging
Current approaches to the early detection of Alzheimer's disease (AD) rely upon classifying
individuals as “positive” or “negative” for biomarkers related to the core pathology of β …
individuals as “positive” or “negative” for biomarkers related to the core pathology of β …
Brain β-amyloid load approaches a plateau
CR Jack Jr, HJ Wiste, TG Lesnick, SD Weigand… - Neurology, 2013 - AAN Enterprises
Objective: To model the temporal trajectory of β-amyloid accumulation using serial amyloid
PET imaging. Methods: Participants, aged 70–92 years, were enrolled in either the Mayo …
PET imaging. Methods: Participants, aged 70–92 years, were enrolled in either the Mayo …
Brain structure and function as mediators of the effects of amyloid on memory
N Mattsson, PS Insel, PS Aisen, W Jagust, S Mackin… - Neurology, 2015 - AAN Enterprises
Objective: The objective of this study was to test whether effects of β-amyloid (Aβ) pathology
on episodic memory were mediated by metabolism and gray matter volume in the early …
on episodic memory were mediated by metabolism and gray matter volume in the early …
Rates of β-amyloid accumulation are independent of hippocampal neurodegeneration
CR Jack Jr, HJ Wiste, DS Knopman, P Vemuri… - Neurology, 2014 - AAN Enterprises
Objective: To test the hypotheses predicted in a hypothetical model of Alzheimer disease
(AD) biomarkers that rates of β-amyloid (Aβ) accumulation on PET imaging are not related to …
(AD) biomarkers that rates of β-amyloid (Aβ) accumulation on PET imaging are not related to …
Association of longitudinal cognitive decline with amyloid burden in middle-aged and older adults: evidence for a dose-response relationship
Importance Presently, the clinical standard for reporting the results of an amyloid positron
emission tomography scan is to assign a dichotomous rating of positive or negative for the …
emission tomography scan is to assign a dichotomous rating of positive or negative for the …
β-Amyloid burden in healthy aging: regional distribution and cognitive consequences
Objective: Several lines of evidence suggest that pathologic changes underlying Alzheimer
disease (AD) begin years prior to the clinical expression of the disease, underscoring the …
disease (AD) begin years prior to the clinical expression of the disease, underscoring the …