The role of diatom glucose-6-phosphate dehydrogenase on lipogenic NADPH supply in green microalgae through plastidial oxidative pentose phosphate pathway

J Xue, TT Chen, JW Zheng, S Balamurugan… - Applied microbiology …, 2018 - Springer
Commercial production of biofuel from oleaginous microalgae is often impeded by their slow
growth rate than other fast-growing algal species. A promising strategy is to genetically …

Glucose‐6‐Phosphate Dehydrogenase from the Oleaginous Microalga Nannochloropsis Uncovers Its Potential Role in Promoting Lipogenesis

J Xue, TT Chen, JW Zheng, S Balamurugan… - Biotechnology …, 2020 - Wiley Online Library
Microalgae have long been considered as potential biological feedstock for the production
of wide array of bioproducts, such as biofuel feedstock because of their lipid accumulating …

Heterologous glucose-6-phosphate dehydrogenase empowers the biofuel potential of Tetradesmus obliquus via generating lipogenic NADPH

J Xue, W Wang, Y Xue, B Li, Y Shi, T Li, D Li, X Wang… - Algal Research, 2024 - Elsevier
Large-scale production of biofuels from oleaginous microalgal feedstocks in a commercially
feasible manner is hampered by their relatively slow growth rates and overall lipid yield than …

Glucose-6-phosphate dehydrogenase as a target for highly efficient fatty acid biosynthesis in microalgae by enhancing NADPH supply

J Xue, S Balamurugan, DW Li, YH Liu, H Zeng… - Metabolic …, 2017 - Elsevier
Oleaginous microalgae have great prospects in the fields of feed, nutrition, biofuel, etc.
However, biomass and lipid productivity in microalgae remain a major economic and …

Enhanced NADPH production in the pentose phosphate pathway accelerates lipid accumulation in the oleaginous diatom Fistulifera solaris

K Osada, Y Maeda, T Yoshino, D Nojima, C Bowler… - Algal research, 2017 - Elsevier
As a consequence of the environmental concerns linked with the exploitation of fossil fuel
reserves, biofuel production using microalgae has been widely considered because of their …

Dual expression of plastidial GPAT1 and LPAT1 regulates triacylglycerol production and the fatty acid profile in Phaeodactylum tricornutum

X Wang, HP Dong, W Wei, S Balamurugan… - Biotechnology for …, 2018 - Springer
Background Metabolic engineering has emerged as a potential strategy for improving
microalgal lipid content through targeted changes to lipid metabolic networks. However, the …

Regulation of malate-pyruvate pathway unifies the adequate provision of metabolic carbon precursors and NADPH in Tetradesmus obliquus

J Xue, T Li, TT Chen, S Balamurugan, WD Yang, HY Li - Algal Research, 2021 - Elsevier
Metabolic engineering has been hailed as a promising tool to impart oil productivity in fast-
growing microalgae, thereby generating industry-suitable strains. However, complex …

Glycerol and neutral lipid production in the oleaginous marine diatom Phaeodactylum tricornutum promoted by overexpression of glycerol-3-phosphate …

Y Yao, Y Lu, KT Peng, T Huang, YF Niu, WH Xie… - Biotechnology for …, 2014 - Springer
Background Microalgae are ideal raw materials for biodiesel and bioactive compounds.
Glycerol-3-phosphate is formed from dihydroxyacetone phosphate (DHAP) through the …

The pivotal role of malic enzyme in enhancing oil accumulation in green microalga Chlorella pyrenoidosa

J Xue, L Wang, L Zhang, S Balamurugan, DW Li… - Microbial cell …, 2016 - Springer
Background The fast growing photosynthetic microalgae have been widely used in
aquaculture, food, health, and biofuels. Recent findings in the diatom has proposed a pivotal …

Enhancing lipid productivity in Nannochloropsis salina by overexpression of endogenous glycerol-3-phosphate dehydrogenase

HG Koh, YK Chang, NK Kang - Journal of Applied Phycology, 2024 - Springer
Microalgae have emerged as a promising feedstock for the sustainable production of lipid-
based products, including biofuels and omega-3 fatty acids, by utilizing CO2 as a carbon …