Human obesity has a large genetic component, yet has many serious negative
consequences. How this state of affairs has evolved has generated wide debate. The thrifty …

The" thrifty gene hypothesis" suggests we evolved genes for efficient food collection and fat
deposition to survive periods of famine and that now that food is continuously available …

Life involves a continuous use of energy, but food intake, which supplies that energy, is
episodic. Feeding is switched on and off by a complex array of predominantly gut-derived …

Almost 50 years ago Neel proposed a hypothesis to explain the prevalence of obesity and
diabetes in modern society—the 'thrifty gene'hypothesis. The fundamental basis of the …

This article challenges Speakman's hypothesis that the modern genetic predisposition to
obesity has arisen through random genetic drift in the two million years following predation …

To explore the logic of evolutionary explanations of obesity we modelled food consumption
in an animal that minimizes mortality (starvation plus predation) by switching between …

The prevalence of obesity in modern societies has two major contributory factors—an
environmental change that has happened in historical times and a genetic predisposition …

The" thrifty gene hypothesis" suggests genetic susceptibility to obesity arises because of
positive selection for alleles that favored fat deposition and survival during famines. We used …

Obesity is an escalating threat of pandemic proportions, currently affecting billions of people
worldwide and exerting a devastating socioeconomic influence in industrialized countries …

People completely lacking body fat (lipodystrophy/lipoatrophy) and those with severe
obesity both show profound metabolic and other health issues. Regulating levels of body fat …