KIBRA is associated with accelerated cognitive decline and hippocampal atrophy in APOE ε4-positive cognitively normal adults with high Aβ-amyloid burden

T Porter, SC Burnham, V Doré, G Savage… - Scientific Reports, 2018 - nature.com
A single nucleotide polymorphism, rs17070145, in the KIdney and BRAin expressed protein
(KIBRA) gene has been associated with cognition and hippocampal volume in cognitively …

Age-dependent association of KIBRA genetic variation and Alzheimer's disease risk

E Rodríguez-Rodríguez, J Infante, J Llorca, I Mateo… - Neurobiology of …, 2009 - Elsevier
An association between memory performance in healthy young, middle aged an elderly
subjects and variability in the KIBRA gene (rs17070145) has been recently described. We …

KL∗ VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗ 4 carriers

ME Belloy, SJ Eger, Y Le Guen, V Napolioni… - Neurobiology of …, 2021 - Elsevier
Abstract KLOTHO∗ VS heterozygosity (KL∗ VS HET+) was recently shown to be associated
with reduced risk of Alzheimer's disease (AD) in APOE∗ 4 carriers. Additional studies …

Genetic association between KIBRA polymorphism and Alzheimer's disease with in a Japanese population

E Kawai, N Shibata, T Nagata, S Shinagawa… - Neuromolecular …, 2015 - Springer
KIBRA plays an important role in synaptic plasticity in human hippocampus related to
cognitive function. Functional studies suggest that KIBRA is a potential candidate gene for …

Association of KIBRA polymorphism with risk of Alzheimer's disease: Evidence based on 20 case-control studies

J Ling, Y Huang, L Zhang, D Wei, W Cheng - Neuroscience Letters, 2018 - Elsevier
Kidney and brain expressed protein (KIBRA) has been demonstrated to play an important
role in episodic memory by genome-wide association study (GWAS). Since memory …

Association of common KIBRA variants with episodic memory and AD risk

JD Burgess, O Pedraza, NR Graff-Radford, M Hirpa… - Neurobiology of …, 2011 - Elsevier
KIBRA single nucleotide polymorphism (SNP) rs17070145 was identified in a genome-wide
association study (GWAS) of memory performance, with some but not all follow-up studies …

Age-dependent association of KIBRA gene polymorphism with Alzheimer's disease in Han Chinese

HF Wang, L Tan, JT Yu, XY Ma, QY Liu… - Molecular biology reports, 2013 - Springer
Genetic factors play an important role in the Alzheimer's disease (AD) development and
memory impairment is a cardinal clinical feature of AD. Kidney and brain expressed protein …

Age-Modulated Associations between KIBRA, Brain Volume, and Verbal Memory among Healthy Older Adults

A Stickel, K Kawa, K Walther, E Glisky… - Frontiers in aging …, 2018 - frontiersin.org
The resource modulation hypothesis suggests that the influence of genes on cognitive
functioning increases with age. The KIBRA single nucleotide polymorphism rs17070145 …

KIBRA and APOE gene variants affect brain functional network connectivity in healthy older people

D Wang, L Hu, X Xu, X Ma, Y Li, Y Liu… - The Journals of …, 2019 - academic.oup.com
Genetic factors play a critical role in the development of Alzheimer's disease (AD). Kidney
and brain expressed protein (KIBRA) and apolipoprotein E (APOE) are involved in episodic …

APOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD

EN Manning, J Barnes, DM Cash, JW Bartlett… - PloS one, 2014 - journals.plos.org
Objectives To investigate whether APOE ε4 carriers have higher hippocampal atrophy rates
than non-carriers in Alzheimer's disease (AD), mild cognitive impairment (MCI) and controls …