Mutations in the LMNA gene, which encodes for the nuclear lamina proteins lamins A and C,
are responsible for a diverse group of diseases known as laminopathies. One type of …

Mutations in the gene for lamin A/C (LMNA) cause a diverse range of diseases known as
laminopathies. LMNA-related cardiomyopathy is a common inherited heart disease and is …

Background Intermediate filament proteins that construct the nuclear lamina of a cell include
the Lamin A/C proteins encoded by the LMNA gene, and are implicated in fundamental …

Mutations of Lamin A/C gene (LMNA) cause laminopathies, a group of disorders associated
with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs …

Rationale: LMNA (Lamin A/C), a nuclear membrane protein, interacts with genome through
lamin-associated domains (LADs) and regulates gene expression. Mutations in the LMNA …

Nuclear lamin A/C are crucial components of the intricate protein mesh that underlies the
inner nuclear membrane and confers mainly nuclear and cytosolic rigidity. However …

Dilated cardiomyopathy (DCM) is a disease of the heart muscle characterized by cardiac
chamber enlargement and reduced systolic function of the left ventricle. Mutations in the …

Abstract Lamin A/C (LMNA) gene mutations are a known cause of familial dilated
cardiomyopathy, but the precise mechanisms triggering disease progression remain …

Mutations in the LMNA gene, which encodes A-type nuclear lamins (intermediate filament
proteins expressed in most differentiated somatic cells), cause a diverse range of diseases …

Mutation in the LMNA gene, encoding lamin A/C, causes a diverse group of diseases called
laminopathies. Cardiac involvement is the major cause of death and manifests as dilated …