Mn porphyrin-based redox-active drugs: differential effects as cancer therapeutics and protectors of normal tissue against oxidative injury
I Batinic-Haberle, A Tovmasyan… - Antioxidants & Redox …, 2018 - liebertpub.com
Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …
[HTML][HTML] Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators
A Tovmasyan, H Sheng, T Weitner… - Medical Principles and …, 2013 - karger.com
Based on aqueous redox chemistry and simple in vivo models of oxidative stress,
Escherichia coli and Saccharomyces cerevisiae, the cationic Mn (III) N-substituted …
Escherichia coli and Saccharomyces cerevisiae, the cationic Mn (III) N-substituted …
Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities
I Batinic-Haberle, I Spasojevic, HM Tse, A Tovmasyan… - Amino acids, 2012 - Springer
The most efficacious Mn (III) porphyrinic (MnPs) scavengers of reactive species have
positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic …
positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic …
H2O2‐Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways
I Batinic-Haberle, A Tovmasyan… - Oxidative medicine …, 2021 - Wiley Online Library
Mn (III) ortho‐N‐alkyl‐and N‐alkoxyalkyl porphyrins (MnPs) were initially developed as
superoxide dismutase (SOD) mimics. These compounds were later shown to react with …
superoxide dismutase (SOD) mimics. These compounds were later shown to react with …
[HTML][HTML] Thiol regulation by Mn porphyrins, commonly known as SOD mimics
I Batinic-Haberle, ME Tome - Redox biology, 2019 - Elsevier
Superoxide dismutases play an important role in human health and disease. Three decades
of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn …
of effort have gone into synthesizing SOD mimics for clinical use. The result is the Mn …
[HTML][HTML] An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins–from superoxide dismutation to H2O2-driven pathways
I Batinic-Haberle, A Tovmasyan, I Spasojevic - Redox biology, 2015 - Elsevier
Most of the SOD mimics thus far developed belong to the classes of Mn-(MnPs) and Fe
porphyrins (FePs), Mn (III) salens, Mn (II) cyclic polyamines and metal salts. Due to their …
porphyrins (FePs), Mn (III) salens, Mn (II) cyclic polyamines and metal salts. Due to their …
Anticancer therapeutic potential of Mn porphyrin/ascorbate system
A Tovmasyan, RS Sampaio, MK Boss… - Free Radical Biology …, 2015 - Elsevier
Ascorbate (Asc) as a single agent suppressed growth of several tumor cell lines in a mouse
model. It has been tested in a Phase I Clinical Trial on pancreatic cancer patients where it …
model. It has been tested in a Phase I Clinical Trial on pancreatic cancer patients where it …
Diverse functions of cationic Mn (III) N-substituted pyridylporphyrins, recognized as SOD mimics
Oxidative stress, a redox imbalance between the endogenous reactive species and
antioxidant systems, is common to numerous pathological conditions such as cancer, central …
antioxidant systems, is common to numerous pathological conditions such as cancer, central …
Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+
T Weitner, I Kos, H Sheng, A Tovmasyan… - Free Radical Biology …, 2013 - Elsevier
The cationic, ortho Mn (III) N-alkylpyridylporphyrins (alkyl= ethyl, E, and n-hexyl, nHex)
MnTE-2-PyP5+ (AEOL10113, FBC-007) and MnTnHex-2-PyP5+ have proven efficacious in …
MnTE-2-PyP5+ (AEOL10113, FBC-007) and MnTnHex-2-PyP5+ have proven efficacious in …
Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate
Due to the ability to easily accept and donate electrons Mn (III) N-alkylpyridylporphyrins
(MnPs) can dismute O2·−, reduce peroxynitrite, but also generate reactive species and …
(MnPs) can dismute O2·−, reduce peroxynitrite, but also generate reactive species and …