Humangenetik überwiesen werden, der den Betroffenen über seine Erkrankungsrisiken
sowie über die Möglichkeit, sich molekulargenetisch testen zu lassen, aufklärt (s. Abb. 5) …

Hereditary nonpolyposis colorectal cancer (HNPCC) is a dominantly‐inherited cancer
predisposition syndrome, in which the susceptibility to cancer of the colon, endometrium and …

Zusammenfassung Hintergrund: Bislang wurden 5 DNA-Reparaturgene identifiziert, deren
Mutationen zu der klinischen Ausprägung eines HNPCC-Syndroms führen können. Der …

22154 Background: Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is associated
with inherited defects in genes involved in postreplicative DNA MisMatch Repair (MMR) …

Subjects affected by hereditary non‐polyposis colorectal cancer exhibit a high susceptibility
to colon and extracolonic tumours, due to MMR gene defects. Revised Bethesda criteria are …

Hereditary nonpolyposis colorectal cancer (HNPCC) is a relatively common autosomal
dominant cancer-susceptibility condition. The recent isolation of the DNA mismatch repair …

The cancer predisposition in most HNPCC families is believed to be associated with
mutations in the human mismatch repair gene homologues hMSH2 and hMLH1. We …

Background: It has been suggested that the detection of MLH1 promoter hypermethylation in
colorectal cancer justifies the diagnosis of a sporadic rather than an inherited defect of the …

Background Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant
disease with a high risk for colorectal and endometrial cancer caused by germline mutations …

A large majority of constitutional mutations in hereditary non‐polyposis colorectal cancer
(HNPCC) are because of the MHL1 or MSH2 genes. In a lower fraction of cases, another …